{"id":"W3126741775","doi":"10.1158/0008-5472.can-20-3892","title":"Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Cancer research; Epithelial–mesenchymal transition; ADAM10; Pancreatic cancer; Medicine; Fibrosis; Cancer; Metastasis; Radiation therapy; Stromal cell; Pathology; Biology; Internal medicine; Metalloproteinase; Matrix metalloproteinase; Disintegrin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008314507,0.0001159243,0.0004502653,0.0002278844,0.0001045379,0.00001832238,0.00007301055,0.0001528061,0.0008650387],"category_scores_gemma":[0.0001951735,0.0001043385,0.00004041155,0.0008536198,0.000246358,0.0001213657,0.00002865821,0.0003735294,0.000004440891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004605027,"about_ca_system_score_gemma":0.001050964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004062291,"about_ca_topic_score_gemma":0.002655913,"domain_scores_codex":[0.9978269,0.0004235441,0.0003103018,0.0003875957,0.0006370249,0.0004146061],"domain_scores_gemma":[0.9987969,0.0002701791,0.00004522261,0.0002459557,0.0004495517,0.0001922048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001786762,0.0002469202,0.09536809,0.0004045007,0.0001217331,0.00002200488,0.00357477,0.00001104945,0.8676549,0.0001578191,0.008237801,0.0224136],"study_design_scores_gemma":[0.006263449,0.0008779708,0.6880576,0.001369818,0.00007092532,0.00001212743,0.00229654,0.0002597283,0.2841239,0.0005648629,0.01585413,0.0002489788],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719062,0.02120325,0.0000431933,0.005041039,0.00006508203,0.0007170522,0.0001073174,0.00001117984,0.0009056787],"genre_scores_gemma":[0.9413504,0.05419949,0.0002768471,0.0001477042,0.0001962525,0.0005337121,0.00004934171,0.00002178407,0.003224452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5926895,"threshold_uncertainty_score":0.9471567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05039197099669572,"score_gpt":0.4051473477458818,"score_spread":0.3547553767491861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}