{"id":"W3126741775","doi":"10.1158/0008-5472.can-20-3892","title":"Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Cancer research; Epithelial–mesenchymal transition; ADAM10; Pancreatic cancer; Medicine; Fibrosis; Cancer; Metastasis; Radiation therapy; Stromal cell; Pathology; Biology; Internal medicine; Metalloproteinase; Matrix metalloproteinase; Disintegrin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410819,0.0002247508,0.0002256398,0.0001623677,0.0001493712,0.0002592732,0.0001129063,0.0002039547,0.001113505],"category_scores_gemma":[0.0001021033,0.0001509858,0.0002742106,0.0001328453,0.0001819284,0.0001433395,0.0001473921,0.0005325759,0.0002677055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056084,"about_ca_system_score_gemma":0.0001610744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003995203,"about_ca_topic_score_gemma":0.0004233691,"domain_scores_codex":[0.9998844,0.00002448948,0.00001355935,0.00002435563,0.00002803433,0.00002512411],"domain_scores_gemma":[0.9999212,0.0000142094,0.00002354402,0.00001392126,0.000007819888,0.00001924266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008514489,0.00003530916,0.000412539,0.00001940206,0.000004535929,0.00004470884,0.00001081763,0.00006429617,0.9985226,0.00003870043,0.00002599478,0.0007360374],"study_design_scores_gemma":[0.00002544687,0.0007006961,0.008640066,0.000004666407,0.00001857037,0.000632753,0.00003225522,0.001237476,0.9872688,0.00004577947,0.00138995,0.000003495571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966599,0.0005698954,0.001759888,0.00005382044,0.00001369815,0.00002734342,0.0001440889,0.00006472715,0.0007066695],"genre_scores_gemma":[0.9972547,0.0004187661,0.001129829,0.00001954934,0.000004668226,0.00003112787,0.0001590999,0.000008226141,0.0009741625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113505,"threshold_uncertainty_score":0.003725052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05039197099669572,"score_gpt":0.4051473477458818,"score_spread":0.3547553767491861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}