{"id":"W3126781502","doi":"10.1038/s41419-021-03417-0","title":"HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China; National Science Foundation","keywords":"HDAC4; Nasopharyngeal carcinoma; Cancer research; Gene knockdown; Epithelial–mesenchymal transition; Biology; Tumor progression; Histone deacetylase; Metastasis; Downregulation and upregulation; HDAC1; Histone; Cell culture; Cancer; Medicine; Internal medicine; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006740419,0.0001373884,0.0001048883,0.00002446339,0.0001334108,0.00005648202,0.0000627293,0.00007270793,0.00004543627],"category_scores_gemma":[0.00007867091,0.0001213029,0.00004757381,0.00005102791,0.00008580706,0.000005964493,0.0001479495,0.00007384911,0.000009392478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007039328,"about_ca_system_score_gemma":0.0003078658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007451535,"about_ca_topic_score_gemma":0.000002391673,"domain_scores_codex":[0.9990333,0.00008228252,0.00009907906,0.0004103082,0.0001380496,0.0002369283],"domain_scores_gemma":[0.9991142,0.00001007738,0.00002438084,0.0002362396,0.00007145735,0.0005436847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004389322,0.0003318278,0.06561212,0.0003569132,0.00002497298,0.0005188442,0.0001167116,9.834165e-7,0.9276958,0.00009694125,0.00118585,0.003620107],"study_design_scores_gemma":[0.001212136,0.0003414357,0.02657626,0.00003353717,0.00004104143,0.00004337436,0.0000674955,0.000193018,0.9593912,0.0005544412,0.01125939,0.0002866345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590125,0.03926655,0.00001584545,0.0002568144,0.00003632177,0.0001933075,0.00002767178,0.00001072268,0.001180244],"genre_scores_gemma":[0.9967758,0.000314113,0.0002254957,0.0002489481,0.0001179134,0.00003576565,0.0002094656,0.00001966762,0.002052837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03903586,"threshold_uncertainty_score":0.4946591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088807856558532,"score_gpt":0.2740693430293333,"score_spread":0.263181264463748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}