{"id":"W3126781502","doi":"10.1038/s41419-021-03417-0","title":"HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China; National Science Foundation","keywords":"HDAC4; Nasopharyngeal carcinoma; Cancer research; Gene knockdown; Epithelial–mesenchymal transition; Biology; Tumor progression; Histone deacetylase; Metastasis; Downregulation and upregulation; HDAC1; Histone; Cell culture; Cancer; Medicine; Internal medicine; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920529,0.0004161917,0.000433272,0.0003491665,0.0002934749,0.0004489301,0.0002739397,0.0002547005,0.003235513],"category_scores_gemma":[0.0001106604,0.0001445669,0.0004494358,0.0003014027,0.0003029122,0.0001797875,0.0002464654,0.000677498,0.0008578565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009125386,"about_ca_system_score_gemma":0.0006119492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00212087,"about_ca_topic_score_gemma":0.004067278,"domain_scores_codex":[0.9998972,0.00001565763,0.000006821655,0.0000189267,0.00002837876,0.00003298893],"domain_scores_gemma":[0.9999598,0.000003833474,0.000008695835,0.000005535122,0.000009775787,0.00001236597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00116123,0.0002502809,0.003751162,0.0004925408,0.0001120652,0.0003602217,0.00004761904,0.0005295679,0.9444996,0.001191589,0.002085776,0.04551835],"study_design_scores_gemma":[0.0002264308,0.001324665,0.02459507,0.0000464775,0.0002574646,0.001055583,0.0001299472,0.002967878,0.9005029,0.0006613333,0.06820826,0.00002407572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8725041,0.08557481,0.009943893,0.001793973,0.0006680141,0.0002732225,0.001580038,0.0009789246,0.026683],"genre_scores_gemma":[0.974096,0.01559906,0.001773775,0.0002016186,0.0000669603,0.00006656315,0.0008476617,0.00003837894,0.007310005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003235513,"threshold_uncertainty_score":0.01082391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088807856558532,"score_gpt":0.2740693430293333,"score_spread":0.263181264463748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}