{"id":"W3126801231","doi":"10.1101/2021.02.03.429526","title":"Sex Differences in Solute and Water Handling in the Human Kidney: Modeling and Functional Implications","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Kidney; Nephron; Endocrinology; Reabsorption; Internal medicine; Sodium; Renal function; Chemistry; Extracellular fluid; Renal sodium reabsorption; Homeostasis; Blood pressure; Excretion; Renal physiology; Biology; Extracellular; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005456089,0.0002658394,0.0003456873,0.000140856,0.0001142337,0.0003738293,0.0003424646,0.0003468615,0.001493789],"category_scores_gemma":[0.0004344021,0.0001085542,0.0006135149,0.0001402678,0.0002105385,0.0002744544,0.0002474862,0.0002423534,0.0002208884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495131,"about_ca_system_score_gemma":0.0005088261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003030819,"about_ca_topic_score_gemma":0.001510803,"domain_scores_codex":[0.9998896,0.00004240097,0.00000457751,0.00003329627,0.00002001988,0.00001018168],"domain_scores_gemma":[0.9998784,0.00005501814,0.00002237682,0.00001441946,0.00001865845,0.00001097127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001306196,0.0004837005,0.162355,0.0005112468,0.0006327274,0.002549385,0.0003762889,0.4975212,0.2178967,0.0212194,0.004475124,0.09067301],"study_design_scores_gemma":[0.0001044558,0.0009908548,0.05706011,0.00004423951,0.0002661042,0.002515915,0.0001946735,0.8956201,0.02264891,0.01368611,0.006813992,0.00005450366],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8804477,0.002574763,0.1125466,0.0008282307,0.00005270645,0.00003743505,0.0006104125,0.0001628218,0.002739308],"genre_scores_gemma":[0.990114,0.0006179141,0.007958505,0.0001028126,0.00001921489,0.00002779374,0.0001538443,0.00001899925,0.0009869033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003030819,"threshold_uncertainty_score":0.006026328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095163933187537,"score_gpt":0.2165558434210758,"score_spread":0.1956042040892005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}