{"id":"W3126810242","doi":"10.1089/nat.2020.0907","title":"Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides","year":2021,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Duchenne muscular dystrophy; Morpholino; Dystrophin; Myogenesis; Exon skipping; Biology; Myocyte; Molecular biology; Cell biology; Immortalised cell line; Cell culture; Exon; Genetics; Alternative splicing; Gene knockdown; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004708825,0.0002986077,0.0003630676,0.0002957461,0.0001668312,0.0002203823,0.0003092649,0.0003644768,0.0010856],"category_scores_gemma":[0.0001719292,0.0001791593,0.0002306369,0.0002374143,0.0001456687,0.0001906071,0.000170996,0.0004929648,0.0008468889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400395,"about_ca_system_score_gemma":0.0002183545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003880213,"about_ca_topic_score_gemma":0.0008113547,"domain_scores_codex":[0.9997329,0.00005610998,0.00004738594,0.00004309682,0.00009332879,0.0000271716],"domain_scores_gemma":[0.9998984,0.00001979843,0.00002176312,0.00001886779,0.00002274809,0.00001828288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001942499,0.00001729347,0.00003475729,0.00003588202,0.000002249924,0.00002336427,0.00001692306,0.00005447607,0.9988392,0.0001336885,0.00005399484,0.0007688375],"study_design_scores_gemma":[0.00001633504,0.00038606,0.0006463559,0.000008220217,0.00002666512,0.0002310291,0.00001634216,0.001251322,0.9870195,0.00004176191,0.01035014,0.000006205075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8863391,0.008200896,0.09303711,0.0003530341,0.0002540378,0.0010346,0.004870475,0.0006742998,0.005236554],"genre_scores_gemma":[0.8933389,0.007843517,0.08290175,0.0001461219,0.00003872318,0.0008419456,0.007602795,0.000124922,0.007161268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010856,"threshold_uncertainty_score":0.003631711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949782994442158,"score_gpt":0.2657346879432024,"score_spread":0.2462368579987808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}