{"id":"W3126810242","doi":"10.1089/nat.2020.0907","title":"Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides","year":2021,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Duchenne muscular dystrophy; Morpholino; Dystrophin; Myogenesis; Exon skipping; Biology; Myocyte; Molecular biology; Cell biology; Immortalised cell line; Cell culture; Exon; Genetics; Alternative splicing; Gene knockdown; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188952,0.0002214646,0.0002639028,0.00003388238,0.0001485746,0.00001103216,0.0001990891,0.0001881581,0.000058559],"category_scores_gemma":[0.00002171135,0.0002164991,0.0001388212,0.000102711,0.00007302788,0.000004463721,0.00009692558,0.00009326285,0.000006875252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001053428,"about_ca_system_score_gemma":0.0002331214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008547197,"about_ca_topic_score_gemma":0.00006180699,"domain_scores_codex":[0.9987978,0.00004971005,0.0003835064,0.0003651026,0.00009942771,0.0003044262],"domain_scores_gemma":[0.9991825,0.00002011585,0.0001731864,0.0003568035,0.0002033443,0.00006408941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002959282,0.0001779375,0.0003311629,0.00008283513,0.0002453084,0.000001659758,0.0004084484,0.00006545047,0.9950874,0.0001247631,0.00009399993,0.003085111],"study_design_scores_gemma":[0.001546848,0.0002003197,0.001826389,0.00002357782,0.00007569705,0.000005007079,0.0005822959,0.0001949167,0.9813318,0.0001654148,0.01377625,0.000271542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992928,0.001684286,0.004209576,0.00008777683,0.0001695619,0.0002009594,0.00002197332,0.00002104431,0.0006767816],"genre_scores_gemma":[0.9903727,0.0002138228,0.008195332,0.0005642527,0.000111926,0.00002997675,0.0002091384,0.00004817124,0.0002546555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01375566,"threshold_uncertainty_score":0.8828579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949782994442158,"score_gpt":0.2657346879432024,"score_spread":0.2462368579987808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}