{"id":"W3126821152","doi":"10.1101/2021.02.10.430527","title":"CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation Institut de Cardiologie de Montréal; Institut de Cardiologie de Montréal; Heart and Stroke Foundation of Canada; Génome Québec; Compute Canada","keywords":"Biology; CRISPR; Phenotype; Genome-wide association study; Gene; Coronary artery disease; Genetics; Furin; Endothelial stem cell; Nitric oxide; Cell biology; Single-nucleotide polymorphism; Internal medicine; Genotype; Medicine; In vitro; Biochemistry; Enzyme; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618833,0.0003211143,0.0002518391,0.0002027794,0.0001562168,0.0003315949,0.0001672915,0.0003105575,0.002910011],"category_scores_gemma":[0.0001644404,0.0001255521,0.0002031322,0.0001234096,0.0002070244,0.00007479885,0.0003053874,0.0004359945,0.0006691189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001742389,"about_ca_system_score_gemma":0.0001158235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005490677,"about_ca_topic_score_gemma":0.0007309553,"domain_scores_codex":[0.9998541,0.00001802587,0.00001241566,0.00003528834,0.00005399829,0.00002617871],"domain_scores_gemma":[0.9999005,0.00003121248,0.00002347396,0.00002049135,0.000007308407,0.00001706115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004959073,0.00001052762,0.000370553,0.00002600967,0.00001013812,0.0001160911,0.00001025736,0.0001963601,0.9972032,0.0001536823,0.0001347852,0.001718884],"study_design_scores_gemma":[0.00001374541,0.00007438263,0.006252157,0.00000628622,0.00002138062,0.0005077398,0.00001498493,0.001743691,0.9864978,0.0001873746,0.004672713,0.000007754855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678445,0.001005007,0.02272895,0.000231717,0.0001041469,0.0000402028,0.002251761,0.001132264,0.004661321],"genre_scores_gemma":[0.9880636,0.0003034581,0.006296409,0.00008783502,0.000008540767,0.00002652483,0.0008526969,0.0001372717,0.004223512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002910011,"threshold_uncertainty_score":0.009734988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00650690413309331,"score_gpt":0.2175959014028113,"score_spread":0.211088997269718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}