{"id":"W3126823073","doi":"10.3390/pharmaceutics13020214","title":"Challenges of Dissolution Methods Development for Soft Gelatin Capsules","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Gelatin; Dosage form; Dissolution; Dissolution testing; Bioavailability; Biochemical engineering; Active ingredient; Drug delivery; Chemistry; Nanotechnology; Materials science; Pharmacology; Chromatography; Medicine; Engineering; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002359451,0.00086818,0.001188818,0.001642279,0.0003229734,0.001464106,0.0009144128,0.001297918,0.002429243],"category_scores_gemma":[0.002124537,0.0006779201,0.00084824,0.0009702247,0.0005541579,0.001851628,0.0008518541,0.00239184,0.002490985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006424552,"about_ca_system_score_gemma":0.001201291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001351538,"about_ca_topic_score_gemma":0.001126385,"domain_scores_codex":[0.9982312,0.0002591408,0.0002268009,0.0002275731,0.0009728319,0.00008240226],"domain_scores_gemma":[0.9990252,0.0004284277,0.000195123,0.00003707213,0.0002795904,0.00003456228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001381599,0.0002113156,0.0004743488,0.03279127,0.0001559205,0.001511788,0.0003911891,0.00206988,0.1434111,0.01344401,0.0147147,0.7906862],"study_design_scores_gemma":[0.00003654233,0.0004809832,0.001470579,0.002942299,0.0001375118,0.003931497,0.0002477984,0.001954334,0.07463728,0.002741504,0.9113286,0.00009115483],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004417452,0.9711364,0.01474786,0.001474236,0.0004542327,0.0001506204,0.0001324985,0.00008313367,0.007403645],"genre_scores_gemma":[0.01656625,0.962026,0.01555111,0.0006661029,0.0002904407,0.0001728129,0.0002029071,0.00003385641,0.004490519],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002429243,"threshold_uncertainty_score":0.01247811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5894093050223294,"score_gpt":0.5978336353421676,"score_spread":0.008424330319838247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}