{"id":"W3126830378","doi":"10.1002/pro.4042","title":"The leucine zipper EF‐hand containing transmembrane protein‐1 EF‐hand is a tripartite calcium, temperature, and pH sensor","year":2021,"lang":"en","type":"article","venue":"Protein Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Leucine zipper; EF hand; Coiled coil; Chemistry; Transmembrane domain; Transmembrane protein; Biophysics; Biochemistry; Crystallography; Membrane; Biology; Peptide sequence; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006554158,0.000185856,0.0001841362,0.00004103623,0.0009853137,0.0003098958,0.0002203909,0.0001468485,0.00005907793],"category_scores_gemma":[0.000368777,0.0001313189,0.00006363933,0.0003465764,0.000933459,0.00001638664,0.0001108068,0.0001898797,0.00001148191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001140435,"about_ca_system_score_gemma":0.0003253263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002180693,"about_ca_topic_score_gemma":0.00006606072,"domain_scores_codex":[0.9982417,0.0001344395,0.0002420477,0.0006832256,0.000266685,0.0004319377],"domain_scores_gemma":[0.9990314,0.00002124836,0.00007311998,0.0004339322,0.0002736354,0.0001667063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002197541,0.00002124172,0.0001010752,0.00002023367,0.000010863,0.00001594282,0.0002746191,0.00000308863,0.9975951,0.000183561,0.0001257675,0.001428792],"study_design_scores_gemma":[0.000976854,0.0003183041,0.0001924085,0.00003632234,0.00001002066,0.0001040931,0.0001690674,0.00005443298,0.9419624,0.00006602138,0.05593043,0.0001796645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924251,0.002550191,0.001353986,0.001999271,0.0002713275,0.0007291327,0.00001783174,0.00001266382,0.0006405319],"genre_scores_gemma":[0.9892497,0.00008421089,0.0009380573,0.0008153224,0.0002521086,0.0001451236,0.00001139412,0.000015141,0.008488942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05580466,"threshold_uncertainty_score":0.7578335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699889932602183,"score_gpt":0.267251544628034,"score_spread":0.2502526453020122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}