{"id":"W3126830378","doi":"10.1002/pro.4042","title":"The leucine zipper EF‐hand containing transmembrane protein‐1 EF‐hand is a tripartite calcium, temperature, and pH sensor","year":2021,"lang":"en","type":"article","venue":"Protein Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Leucine zipper; EF hand; Coiled coil; Chemistry; Transmembrane domain; Transmembrane protein; Biophysics; Biochemistry; Crystallography; Membrane; Biology; Peptide sequence; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007796919,0.0003011982,0.0002067658,0.0001379697,0.0002832367,0.0002429144,0.0001891297,0.0004169736,0.001420725],"category_scores_gemma":[0.0001063433,0.00009456734,0.0001697924,0.0001121735,0.0001417239,0.0001663108,0.0001936132,0.0002744238,0.0008833728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004253022,"about_ca_system_score_gemma":0.0001115989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003408389,"about_ca_topic_score_gemma":0.0004216378,"domain_scores_codex":[0.9999247,0.00001018255,0.000004212272,0.00002268907,0.00001899728,0.00001935638],"domain_scores_gemma":[0.9999218,0.000008594807,0.00002568854,0.000004645845,0.000009790325,0.00002949073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001308235,0.00001016867,0.0004813268,0.00003593208,0.000005364017,0.000176247,0.00001005128,0.0001498442,0.9970957,0.0001334921,0.000203218,0.001567727],"study_design_scores_gemma":[0.00005767048,0.0002833123,0.04527284,0.00003177661,0.00002971976,0.002872726,0.00008429545,0.009126023,0.9191213,0.0006112886,0.02246948,0.00003963472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878797,0.002034185,0.006633034,0.0002314638,0.00006905981,0.00002905659,0.0009775793,0.0002432327,0.001902767],"genre_scores_gemma":[0.9902762,0.0003132093,0.004093394,0.0001222447,0.00001954404,0.00001873017,0.00149139,0.00001515351,0.003649994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420725,"threshold_uncertainty_score":0.004752815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699889932602183,"score_gpt":0.267251544628034,"score_spread":0.2502526453020122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}