{"id":"W3126837131","doi":"10.1002/1878-0261.12926","title":"DNA methylation markers have universal prognostic value for anal cancer risk in HIV‐negative and HIV‐positive individuals","year":2021,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"KWF Kankerbestrijding; ZonMw; Aids Fonds","keywords":"Anal cancer; DNA methylation; Methylation; Oncology; Internal medicine; Cancer; Medicine; Men who have sex with men; Human immunodeficiency virus (HIV); Biology; Immunology; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000925042,0.0002237677,0.0002689812,0.0005163183,0.0001922449,0.0005188969,0.0001717152,0.0003703919,0.001092255],"category_scores_gemma":[0.00310297,0.0001708876,0.0002571108,0.0004827009,0.0002199597,0.0002670812,0.0003800557,0.0003811982,0.0001509432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168797,"about_ca_system_score_gemma":0.0001384756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173732,"about_ca_topic_score_gemma":0.001560734,"domain_scores_codex":[0.9996912,0.0001109369,0.00002647301,0.00007599579,0.00005229883,0.00004312553],"domain_scores_gemma":[0.9985587,0.0007136971,0.0003847079,0.0001284893,0.0001152292,0.00009919959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001746498,0.000009065359,0.9907812,0.00001428982,0.00005609815,0.00002152377,0.00003603072,0.0001041757,0.001869968,0.00001742164,0.00003456782,0.00688088],"study_design_scores_gemma":[0.000003684313,0.00012378,0.9956822,0.00001574762,0.00008342728,0.0002633967,0.0000771513,0.001678232,0.001704396,0.0001207907,0.0002414088,0.000005809532],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967615,0.001562885,0.0009334538,0.00004593875,0.000007183782,0.000008537251,0.0002595907,0.00002039937,0.000400689],"genre_scores_gemma":[0.9990676,0.0001820224,0.0004959962,0.00001270666,0.000005512869,0.000003397994,0.0001272325,0.000001867011,0.000103745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173732,"threshold_uncertainty_score":0.00489217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944721794115791,"score_gpt":0.357336927119552,"score_spread":0.3378897091783941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}