{"id":"W3126850438","doi":"10.1126/sciimmunol.aba0178","title":"E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Blood Cancer UK; Belgian American Educational Foundation","keywords":"Haematopoiesis; Progenitor cell; Basophil; Mast cell; Biology; Immunology; Cell biology; Cell; Stem cell; Antibody; Genetics; Immunoglobulin E","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000914886,0.0001897929,0.0001281576,0.0003718226,0.0001290093,0.0002745005,0.0001801135,0.0002847025,0.001498225],"category_scores_gemma":[0.00008268327,0.0002665986,0.0001586545,0.0001591362,0.0002640699,0.0001699969,0.0001874411,0.0005096926,0.000489092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642444,"about_ca_system_score_gemma":0.0001175727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004370014,"about_ca_topic_score_gemma":0.0009122455,"domain_scores_codex":[0.9998386,0.00001808921,0.00001034615,0.00004144411,0.00003708197,0.00005446358],"domain_scores_gemma":[0.999896,0.00001483113,0.00003215112,0.00001061356,0.00000909301,0.00003722573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004750301,0.000006634811,0.000207683,0.000008932406,9.940572e-7,0.00004442915,0.00001017181,0.00002822551,0.9988746,0.0001562342,0.00002177318,0.0005928738],"study_design_scores_gemma":[0.0000165817,0.00008137474,0.01834692,0.000007768191,0.000007647106,0.0002712445,0.00003022941,0.0009713665,0.977576,0.0001316798,0.002555202,0.000003974393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899487,0.0008287564,0.005919904,0.00006690672,0.00001670363,0.00002223088,0.0006568992,0.0001300035,0.002409809],"genre_scores_gemma":[0.9874949,0.0005017127,0.00383681,0.0000559397,0.000006878427,0.00003510232,0.0008563722,0.00005825491,0.007154139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498225,"threshold_uncertainty_score":0.005012035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006048503226471586,"score_gpt":0.2022564370209029,"score_spread":0.1962079337944314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}