{"id":"W3126869189","doi":"10.1016/j.hoc.2020.09.005","title":"Advanced Melanoma","year":2020,"lang":"en","type":"review","venue":"Hematology/Oncology Clinics of North America","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Merck; Bristol-Myers Squibb","keywords":"Melanoma; Acquired resistance; Medicine; Innate immune system; Metastatic melanoma; Cancer research; Immunology; Cancer; Immune system; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001897165,0.0007307068,0.004253479,0.0001503513,0.00008052639,0.000005718549,0.00100346,0.001237359,0.00005913511],"category_scores_gemma":[0.000715248,0.0006624423,0.001138199,0.0003713574,0.000620116,0.000004102958,0.0005906677,0.0007056041,0.0003220151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003732802,"about_ca_system_score_gemma":0.001626757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003785518,"about_ca_topic_score_gemma":0.0000368087,"domain_scores_codex":[0.9957138,0.0005301961,0.001818246,0.001156868,0.0001745805,0.0006062684],"domain_scores_gemma":[0.9960138,0.0003796446,0.002053182,0.001073309,0.0001620481,0.0003180301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009855869,0.0001958922,0.0003737774,0.002970374,0.0005231291,0.0001957053,0.0000179889,0.000001275686,0.000006993627,0.00009142225,0.004704228,0.9908206],"study_design_scores_gemma":[0.0005264173,0.002629565,0.00001626729,0.000408941,0.0006266745,0.0004429728,0.0000199664,0.000002899714,0.00002436429,0.00001868936,0.9947317,0.0005515974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004964051,0.9944607,0.00031328,0.00007777964,0.000864277,0.0008530865,0.0002998278,0.00004690291,0.002587753],"genre_scores_gemma":[0.0002041335,0.9927041,0.003993671,0.0005097601,0.0003332106,0.0002243345,0.001728965,0.0001128541,0.0001889911],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9902691,"threshold_uncertainty_score":0.9995827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186428674690726,"score_gpt":0.3485917963956079,"score_spread":0.3167275096487006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}