{"id":"W3126877319","doi":"10.1002/bit.27703","title":"Autophagy‐inducing peptide increases CHO cell monoclonal antibody production in batch and fed‐batch cultures","year":2021,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; BC Centre for Disease Control; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Saskatchewan Health Research Foundation","keywords":"Chinese hamster ovary cell; Autophagy; Bioprocess; Hydrolysate; Biology; Monoclonal antibody; Cell biology; Cell culture; Fed-batch culture; Recombinant DNA; Biochemistry; Chemistry; Antibody; Fermentation; Receptor; Immunology; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007194804,0.0001655007,0.0001432224,0.00008422202,0.0001013016,0.00002283932,0.00006191513,0.0003495496,0.000004952885],"category_scores_gemma":[0.00007006677,0.0001575495,0.00003543691,0.0001510638,0.00007850081,0.000009753038,0.0001639746,0.0001734774,0.000001218782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063817,"about_ca_system_score_gemma":0.00003133552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005223198,"about_ca_topic_score_gemma":0.00004154309,"domain_scores_codex":[0.9990943,0.0000226624,0.0001557275,0.0004497088,0.00005121673,0.0002263701],"domain_scores_gemma":[0.9996722,0.000006231148,0.00003811594,0.000193072,0.0000303319,0.00006009806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002603198,0.00006620691,0.009222166,0.00006037921,0.0000217966,0.00002244718,0.00001982942,0.0002494751,0.9885997,0.00004105242,0.0002155644,0.001455366],"study_design_scores_gemma":[0.0003256196,0.0001319346,0.01023399,0.00005315536,0.00001429114,0.0001480192,0.0001328193,0.0002533621,0.9846566,0.00004245951,0.003791114,0.0002166522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914361,0.007451442,0.0003623333,0.0003290206,0.0001731303,0.0001155159,0.000008922666,0.00007743108,0.00004608771],"genre_scores_gemma":[0.9955294,0.003131475,0.0008811047,0.00006027074,0.0001517614,0.00002108371,0.00005124658,0.00001821819,0.0001554516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319967,"threshold_uncertainty_score":0.642468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004794694070330717,"score_gpt":0.2388756402287583,"score_spread":0.2340809461584275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}