{"id":"W3126877319","doi":"10.1002/bit.27703","title":"Autophagy‐inducing peptide increases CHO cell monoclonal antibody production in batch and fed‐batch cultures","year":2021,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; BC Centre for Disease Control; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Saskatchewan Health Research Foundation","keywords":"Chinese hamster ovary cell; Autophagy; Bioprocess; Hydrolysate; Biology; Monoclonal antibody; Cell biology; Cell culture; Fed-batch culture; Recombinant DNA; Biochemistry; Chemistry; Antibody; Fermentation; Receptor; Immunology; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000509519,0.0005732649,0.0005522381,0.0004749073,0.0001625424,0.0005853949,0.0004256463,0.0004573482,0.0009452574],"category_scores_gemma":[0.000345513,0.0002128192,0.0004798135,0.0004417198,0.0001811011,0.0003186533,0.0003913156,0.0007154922,0.0006930425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005480695,"about_ca_system_score_gemma":0.0002456989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009037025,"about_ca_topic_score_gemma":0.001643605,"domain_scores_codex":[0.999545,0.00006619491,0.00006023599,0.0001080727,0.0001633882,0.00005702724],"domain_scores_gemma":[0.9996581,0.00009911315,0.0000634003,0.00005073581,0.00007178011,0.00005691035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004425809,0.00003662971,0.00007730645,0.00001942903,0.000003649771,0.00001430342,0.000009470669,0.00003640412,0.9991129,0.00001121966,0.00001734132,0.0006169807],"study_design_scores_gemma":[0.000006295842,0.0002849507,0.001260376,0.00000377219,0.00001363537,0.00003683632,0.00000771892,0.0003620723,0.9973611,0.000009070692,0.0006496974,0.000004418292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824843,0.001812903,0.009900615,0.000124311,0.00008323727,0.0001845805,0.001367404,0.0003654774,0.003677086],"genre_scores_gemma":[0.9480767,0.001777734,0.03475687,0.000171538,0.00004864931,0.0002382005,0.003554218,0.0002397539,0.01113639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009452574,"threshold_uncertainty_score":0.003976524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004794694070330717,"score_gpt":0.2388756402287583,"score_spread":0.2340809461584275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}