{"id":"W3126881335","doi":"10.1038/s41391-021-00322-7","title":"ZRSR2 overexpression is a frequent and early event in castration-resistant prostate cancer development","year":2021,"lang":"en","type":"article","venue":"Prostate Cancer and Prostatic Diseases","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Prevention of Organ Failure; BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Prostate cancer; Transcriptome; Androgen deprivation therapy; Androgen receptor; Gene knockdown; Gene expression profiling; Medicine; Oncology; Biology; Cancer research; Gene; Bioinformatics; Cancer; Gene expression; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000140859,0.0003831654,0.0005204392,0.0001636618,0.0002366886,0.0001825989,0.00005966932,0.0000757241,0.0002883191],"category_scores_gemma":[0.00005051729,0.0003022077,0.00006617592,0.0003715068,0.0001974474,0.000290348,0.0001271447,0.0002289,0.000004447803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377312,"about_ca_system_score_gemma":0.002057222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008884363,"about_ca_topic_score_gemma":0.0003013595,"domain_scores_codex":[0.9973171,0.00007732482,0.0005715255,0.000799935,0.0005780069,0.0006561279],"domain_scores_gemma":[0.9986893,0.00007460939,0.0001386687,0.0002528584,0.0002976958,0.0005468573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003630639,0.0006672525,0.850569,0.003336249,0.0003133284,0.0007743968,0.01653955,0.00001965449,0.02306254,0.0000708548,0.001066015,0.09995051],"study_design_scores_gemma":[0.00945618,0.0004766203,0.930059,0.004498409,0.0002505115,0.00003168624,0.001715476,0.000125888,0.04242644,0.001009593,0.009305375,0.0006448633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252924,0.06865884,0.000002646415,0.00330532,0.00009688721,0.001755055,0.0007053498,0.00004399328,0.0001395342],"genre_scores_gemma":[0.9696305,0.02196687,0.0003845077,0.0005955531,0.00006163684,0.002038356,0.0001872005,0.00005391576,0.005081393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09930565,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249057694112454,"score_gpt":0.3309283767807692,"score_spread":0.3084377998396446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}