{"id":"W3126883416","doi":"10.1101/2021.01.31.428988","title":"Environmental enrichment induces epigenomic and genome organization changes relevant for cognitive function","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"Social Sciences and Humanities Research Council of Canada; National Science Foundation; Ministerio de Economía y Competitividad; Generalitat de Catalunya; Centres de Recerca de Catalunya; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Epigenome; CTCF; Chromatin; Epigenomics; Biology; Genome; Enhancer; Genetics; Transcription factor; ChIA-PET; Genomic organization; Computational biology; Gene; DNA methylation; Chromatin remodeling; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007090761,0.0001840964,0.0001715056,0.0002467734,0.00009634723,0.0002085104,0.000127128,0.0001738427,0.001715655],"category_scores_gemma":[0.0001077856,0.0001236815,0.0002109828,0.0001283312,0.0001826842,0.0001225777,0.0002894198,0.0003390115,0.0001647972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776211,"about_ca_system_score_gemma":0.000126726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005707086,"about_ca_topic_score_gemma":0.001340478,"domain_scores_codex":[0.9999135,0.000008542892,0.00000398052,0.00002989065,0.00001819132,0.00002592194],"domain_scores_gemma":[0.9998647,0.00001729179,0.00004922376,0.00001548478,0.00001958473,0.00003376263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007518142,0.000007055945,0.00257018,0.00001646668,0.00001011131,0.00003797501,0.00001332639,0.00005338253,0.9957452,0.00005702399,0.00003189283,0.001382214],"study_design_scores_gemma":[0.000009191515,0.0002699968,0.4140013,0.00001356,0.00006434634,0.0005535235,0.0001311774,0.001229984,0.5803835,0.0002725457,0.003056936,0.00001393707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940729,0.0006492534,0.003636742,0.00004215821,0.00001154235,0.000007878696,0.0006551991,0.00007419813,0.000850219],"genre_scores_gemma":[0.9957442,0.0003319656,0.001485446,0.00005661741,0.000005290109,0.00002337404,0.000730741,0.00002770783,0.001594639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715655,"threshold_uncertainty_score":0.00573945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00969100299977384,"score_gpt":0.2054437730688639,"score_spread":0.1957527700690901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}