{"id":"W3126943721","doi":"10.1017/s0033291720005218","title":"Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments","year":2021,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Agència de Gestió d'Ajuts Universitaris i de Recerca; Medical Research Council; Canadian Institutes of Health Research; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; State University of New York Upstate Medical University; National Institutes of Health; Universität Heidelberg; Universitat Autònoma de Barcelona; Centro de Investigación Biomédica en Red de Salud Mental; Syddansk Universitet; Hospital for Sick Children; Instituto de Salud Carlos III; Radboud Universiteit; Universitat de Barcelona; Universiteit Gent; European Regional Development Fund; Universität Zürich; Universitat de València; University of Toronto; Universitätsmedizin Göttingen; Universität Duisburg-Essen; Wellcome Trust; King's College London; National Institute of Mental Health; Horizon 2020 Framework Programme; Universität Basel; State University of New York; Cardiff University; European Commission; Icahn School of Medicine at Mount Sinai; National Institute of Neurological Disorders and Stroke; Syracuse University; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Generalitat de Catalunya; David Geffen School of Medicine, University of California, Los Angeles; Massachusetts General Hospital","keywords":"Genome-wide association study; Attention deficit hyperactivity disorder; Association (psychology); Genetic association; Psychology; Cognition; Genetic architecture; Clinical psychology; Medicine; Psychiatry; Single-nucleotide polymorphism; Genetics; Quantitative trait locus; Genotype; Biology; Population; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007298926,0.0002949792,0.0007655184,0.0001006579,0.0002758213,0.00001821069,0.00006410137,0.0003241791,0.001652542],"category_scores_gemma":[0.004556041,0.0002313454,0.0001586502,0.0005200668,0.000221634,0.00017793,0.0001245968,0.0006800932,0.000128886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393221,"about_ca_system_score_gemma":0.00002350068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004013029,"about_ca_topic_score_gemma":0.00001157772,"domain_scores_codex":[0.9971332,0.0003889635,0.0005164518,0.0008278629,0.0006842618,0.0004492809],"domain_scores_gemma":[0.9975437,0.001101832,0.0002455163,0.0003492904,0.0004477527,0.0003118858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001236124,0.001183832,0.9730345,0.00005117231,0.0002789036,0.0000708515,0.00008793018,9.855374e-8,0.003445633,0.00002173686,0.00007962799,0.02162209],"study_design_scores_gemma":[0.005168038,0.0007212075,0.990718,0.0001511895,0.0007301329,0.0001713474,0.001484182,0.00001781442,0.000007999036,0.0001901228,0.0004222097,0.0002177399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799132,0.0008437395,0.0008745726,0.01395235,0.0002981883,0.0005417433,0.00003448721,0.0001333118,0.003408431],"genre_scores_gemma":[0.9959745,0.0002021562,0.0001661004,0.0009815461,0.0003387088,0.00004681525,0.0002120139,0.00002725183,0.002050896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02140435,"threshold_uncertainty_score":0.9992601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0464223526151616,"score_gpt":0.3812055110727868,"score_spread":0.3347831584576252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}