{"id":"W3126975289","doi":"10.1016/j.ajo.2021.01.027","title":"Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend for Macular Edema in Central Retinal Vein Occlusion: the CENTERA Study","year":2021,"lang":"en","type":"article","venue":"American Journal of Ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Allergan; Heidelberg Engineering; Bayer HealthCare; European Commission; Novartis; Roche; Pharmaceutical Research and Manufacturers of America Foundation; Bayer; European Federation of Pharmaceutical Industries and Associations","keywords":"Aflibercept; Medicine; Central retinal vein occlusion; Macular edema; Visual acuity; Ophthalmology; Confidence interval; Retinal; Regimen; Surgery; Bevacizumab; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002212631,0.001357021,0.001538564,0.0003721275,0.00051307,0.0008886085,0.0006981748,0.0009214921,0.002689483],"category_scores_gemma":[0.0008319463,0.0004074523,0.0014112,0.0003153431,0.0007613175,0.0006919509,0.0004601037,0.001580994,0.0005159865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007024023,"about_ca_system_score_gemma":0.001204412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233542,"about_ca_topic_score_gemma":0.003157937,"domain_scores_codex":[0.999135,0.0004094607,0.00005219854,0.0001325106,0.0001383492,0.0001324995],"domain_scores_gemma":[0.9990031,0.0001299699,0.0002879842,0.00009972134,0.00007215455,0.0004071008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6571479,0.08277926,0.04301616,0.000912272,0.004577955,0.0003199842,0.0003656778,0.001005812,0.03698661,0.0003191436,0.005490801,0.1670784],"study_design_scores_gemma":[0.5279663,0.3173178,0.1417766,0.00009573863,0.002256348,0.0005140812,0.00009548059,0.001374785,0.004321528,0.0001958522,0.003985809,0.00009972061],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936368,0.002717174,0.0002267719,0.0001574677,0.00004513204,0.0009795009,0.0006781463,0.00004939297,0.001509519],"genre_scores_gemma":[0.9958518,0.0009281308,0.0004487807,0.0003247019,0.0001535432,0.000560217,0.000709092,0.00001001589,0.001013787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002689483,"threshold_uncertainty_score":0.01170164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449351246406609,"score_gpt":0.3221202812856633,"score_spread":0.3076267688215972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}