{"id":"W3126975289","doi":"10.1016/j.ajo.2021.01.027","title":"Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend for Macular Edema in Central Retinal Vein Occlusion: the CENTERA Study","year":2021,"lang":"en","type":"article","venue":"American Journal of Ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Allergan; Heidelberg Engineering; Bayer HealthCare; European Commission; Novartis; Roche; Pharmaceutical Research and Manufacturers of America Foundation; Bayer; European Federation of Pharmaceutical Industries and Associations","keywords":"Aflibercept; Medicine; Central retinal vein occlusion; Macular edema; Visual acuity; Ophthalmology; Confidence interval; Retinal; Regimen; Surgery; Bevacizumab; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002002116,0.0001492114,0.0006346808,0.00007969161,0.00005723666,0.000008931822,0.0000764458,0.0000310332,0.00008692015],"category_scores_gemma":[0.0001214432,0.00009508742,0.0001308975,0.0001696894,0.0003150865,0.00003377319,0.00006226687,0.0001610122,3.240422e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004671908,"about_ca_system_score_gemma":0.0001203511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006994503,"about_ca_topic_score_gemma":0.000001880436,"domain_scores_codex":[0.9986233,0.0002624665,0.0004926333,0.0001985655,0.0001740382,0.0002489872],"domain_scores_gemma":[0.9989387,0.0002712256,0.0003165422,0.0001620472,0.0001295894,0.0001818272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01408881,0.002599232,0.934052,0.00004869927,0.0004782468,0.01782783,0.001949026,0.000007739913,0.0005366328,0.0000399314,0.00003956248,0.02833233],"study_design_scores_gemma":[0.006354467,0.009146553,0.9397716,0.0001061622,0.0004302944,0.04011525,0.003807032,0.00001796264,0.00006261931,0.00005782117,0.00006312116,0.00006710001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996873,0.0009850841,0.00001016872,0.001362959,0.00006014609,0.0003484742,0.00001748448,0.000001587367,0.0003411451],"genre_scores_gemma":[0.998999,0.0002238136,0.000521992,0.00006254304,0.00007828937,0.000004207901,0.000008954383,0.0000139769,0.00008722011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02826523,"threshold_uncertainty_score":0.3877552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449351246406609,"score_gpt":0.3221202812856633,"score_spread":0.3076267688215972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}