{"id":"W3127161418","doi":"10.1039/d0sc05442a","title":"Rapid synthesis of pomalidomide-conjugates for the development of protein degrader libraries","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Children's Hospital Foundation; Cancer Research Institute; Alberta Children's Hospital Research Institute; Children's Hospital Foundation; University of Calgary","keywords":"Pomalidomide; Conjugate; Chemistry; Computer science; Computational biology; Nanotechnology; Medicine; Materials science; Biology; Internal medicine; Mathematics; Multiple myeloma; Lenalidomide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426514,0.0000588938,0.00008448445,0.00001291599,0.00007650659,0.00001638495,0.000272385,0.00004280747,0.00002162124],"category_scores_gemma":[0.001203979,0.00003968463,0.00004819394,0.0001680162,0.0005108558,0.000007233135,0.0001310355,0.00002402875,5.609349e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005745637,"about_ca_system_score_gemma":0.0003750026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.6801e-7,"about_ca_topic_score_gemma":6.714671e-7,"domain_scores_codex":[0.9993457,0.00001023377,0.0001907816,0.0001847949,0.0001423342,0.0001262177],"domain_scores_gemma":[0.9995113,0.00005099647,0.00007405804,0.0001859047,0.000139448,0.0000382997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001762875,0.00002406724,0.00005790864,0.00002187614,0.000007869138,4.120224e-8,0.00003699549,2.789306e-7,0.9883121,0.0005094648,0.0001018721,0.01090989],"study_design_scores_gemma":[0.00009542618,0.00001313822,0.0001237323,0.00002176605,0.000003934108,8.711665e-7,0.00008749984,0.00001842226,0.9920321,0.0001484903,0.007398243,0.00005639269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958941,0.001011646,0.001830974,0.0004787288,0.0000399705,0.0002066025,0.000006460538,0.000004164885,0.0005273823],"genre_scores_gemma":[0.9766192,0.00001035393,0.02310941,0.00004347644,0.00002972751,0.00006661434,0.000005901637,0.000003858967,0.0001114881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02127844,"threshold_uncertainty_score":0.188227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843710490193446,"score_gpt":0.2432485153797468,"score_spread":0.2248114104778124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}