{"id":"W3127162284","doi":"10.1158/0008-5472.can-20-3267","title":"Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Human Genome Research Institute; National Center for Chronic Disease Prevention and Health Promotion; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; Centers for Disease Control and Prevention; Division of Cancer Epidemiology and Genetics, National Cancer Institute; University of California, San Francisco; Ministero della Salute; Lustgarten Foundation; California Department of Public Health; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Grantová Agentura České Republiky; European Cooperation in Science and Technology; Ministerio de Ciencia y Tecnología; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Medical Research Council; Pancreatic Cancer Action Network; Patient-Centered Outcomes Research Institute; Ministerstvo Zdravotnictví Ceské Republiky; American Cancer Society; State of Connecticut Department of Public Health; Kaiser Permanente; U.S. Department of Defense; World Health Organization; Geoffrey Beene Foundation; Cancer Council Victoria; Yale University; National Institutes of Health; Promises for Purple; U.S. Department of Health and Human Services","keywords":"Expression quantitative trait loci; Quantitative trait locus; Pancreatic cancer; Genotype; Colocalization; Linkage disequilibrium; Allele; Locus (genetics); SNP","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006348841,0.0004153199,0.0003309178,0.0008682482,0.0003200535,0.0006759063,0.0003526359,0.0004642557,0.003203289],"category_scores_gemma":[0.001694912,0.0002363068,0.0007890535,0.001009621,0.0002531226,0.0001483027,0.0003293875,0.000424721,0.0003526117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693264,"about_ca_system_score_gemma":0.0001987851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004551454,"about_ca_topic_score_gemma":0.003087074,"domain_scores_codex":[0.9993781,0.000239905,0.00003726504,0.0001828068,0.00009996314,0.00006194109],"domain_scores_gemma":[0.9990708,0.0003397813,0.0003243849,0.0000922496,0.0000709516,0.000101827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009625488,0.00008175565,0.9361853,0.00004151967,0.0006845166,0.0008214176,0.0001505912,0.0003328319,0.05447086,0.0001709075,0.0002952437,0.005802451],"study_design_scores_gemma":[0.0000278604,0.00007993614,0.9958126,0.000008114391,0.0002233866,0.0006312238,0.00003580565,0.000707411,0.001941909,0.0001526658,0.0003728132,0.000006161674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972994,0.0004136072,0.0009208884,0.0001254501,0.00001688025,0.000009077927,0.0004915952,0.00004822914,0.0006749641],"genre_scores_gemma":[0.9990259,0.00006796287,0.0002960817,0.00003431542,0.00001611124,0.000006839868,0.0002127445,0.00001342045,0.0003265894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004551454,"threshold_uncertainty_score":0.01071614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1514967973984099,"score_gpt":0.4764570425719832,"score_spread":0.3249602451735733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}