{"id":"W3127163105","doi":"10.1101/2021.02.09.429966","title":"Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Amsterdam University Medical Centers; Universität Konstanz; Universitair Medisch Centrum Utrecht; Wageningen University and Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit Leiden; Health~Holland","keywords":"Biofilm; Staphylococcus aureus; Teichoic acid; Microbiology; Monoclonal antibody; In vivo; Antibiotics; In vitro; Antibody; Biology; Staphylococcal infections; Antigen; Bacteria; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003408047,0.0004623437,0.0001693776,0.0002436028,0.000113828,0.0003039148,0.0001716681,0.0005031593,0.003845271],"category_scores_gemma":[0.0002588836,0.0001196396,0.0002600964,0.0001240635,0.0001414773,0.0001465101,0.0001372106,0.0004386799,0.001349923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271493,"about_ca_system_score_gemma":0.0001261572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007408667,"about_ca_topic_score_gemma":0.0005706879,"domain_scores_codex":[0.9998409,0.00003738915,0.00001083783,0.00003921082,0.00003593667,0.00003569907],"domain_scores_gemma":[0.9999074,0.00003288287,0.00001231393,0.00001323542,0.0000198144,0.00001438899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000121981,0.00005761413,0.0008485561,0.00006589317,0.00001520865,0.00005344763,0.0000277776,0.0001257321,0.9924592,0.000341559,0.001071321,0.004811677],"study_design_scores_gemma":[0.00003795227,0.0003506017,0.007359678,0.00002115618,0.00004102903,0.000614144,0.00003208964,0.0015842,0.9706077,0.0002522364,0.01909268,0.000006499342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9184321,0.008075194,0.04816809,0.001131511,0.0003888435,0.0001794206,0.001614334,0.0007518543,0.02125858],"genre_scores_gemma":[0.9548156,0.002161746,0.01970539,0.0005893192,0.0001019269,0.0001321485,0.002434563,0.0001363492,0.01992293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003845271,"threshold_uncertainty_score":0.0128637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009302786662113531,"score_gpt":0.2190441723980491,"score_spread":0.2097413857359355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}