{"id":"W3127170592","doi":"10.3390/cancers13040732","title":"The Underlying Biology and Therapeutic Vulnerabilities of Leptomeningeal Metastases in Adult Solid Cancers","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; McGill University Health Centre","funders":"Terry Fox Foundation","keywords":"Leptomeninges; Medicine; Subarachnoid space; Cerebrospinal fluid; Pathology; Parenchyma; Central nervous system; Metastasis; Pia mater; Infiltration (HVAC); Melanoma; Brain metastasis; Meningeal carcinomatosis; Cancer; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003300374,0.0003217992,0.001738855,0.0001224876,0.00009414267,0.00001767488,0.00009802627,0.000130177,0.00005292833],"category_scores_gemma":[0.00009907439,0.0001889795,0.000298554,0.0002797466,0.000414298,0.0000170133,0.00004608579,0.0003122619,8.095954e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00175527,"about_ca_system_score_gemma":0.002779099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00194925,"about_ca_topic_score_gemma":0.0009006506,"domain_scores_codex":[0.9982549,0.0003551163,0.0005417916,0.0003810045,0.0001301459,0.0003370576],"domain_scores_gemma":[0.9984472,0.0007746606,0.0002604265,0.0003555423,0.00007952555,0.00008265235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002332218,0.00001053961,0.00005967348,0.004450452,0.001181741,0.00002402434,0.0002158541,0.00001964697,0.000001172381,0.001690087,0.00007778797,0.9922457],"study_design_scores_gemma":[0.001153876,0.0004860741,0.00001897643,0.01095363,0.002784137,0.00008985592,0.002513869,0.00003009913,0.00001496709,0.0001689321,0.9815003,0.000285319],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005929218,0.9980359,0.00001046025,0.0001065228,0.0002571775,0.0006516388,0.0001514493,0.00001099634,0.0001829492],"genre_scores_gemma":[0.004844815,0.9942804,0.0001244018,0.0001151614,0.00006161171,0.0003078971,0.00009920746,0.00003488371,0.0001316523],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9919604,"threshold_uncertainty_score":0.770636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09864573449559158,"score_gpt":0.4171984688543284,"score_spread":0.3185527343587369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}