{"id":"W3127170592","doi":"10.3390/cancers13040732","title":"The Underlying Biology and Therapeutic Vulnerabilities of Leptomeningeal Metastases in Adult Solid Cancers","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; McGill University Health Centre","funders":"Terry Fox Foundation","keywords":"Leptomeninges; Medicine; Subarachnoid space; Cerebrospinal fluid; Pathology; Parenchyma; Central nervous system; Metastasis; Pia mater; Infiltration (HVAC); Melanoma; Brain metastasis; Meningeal carcinomatosis; Cancer; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095052,0.0004679,0.0007057815,0.001169567,0.0002036558,0.0006923454,0.0004880446,0.0006666309,0.002741483],"category_scores_gemma":[0.0005958877,0.0001565759,0.0004294804,0.001016213,0.0002895101,0.0008223679,0.0004203185,0.0011128,0.0009253316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004690896,"about_ca_system_score_gemma":0.0008063272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000772356,"about_ca_topic_score_gemma":0.001763241,"domain_scores_codex":[0.9998869,0.00002048079,0.00001771343,0.00001930064,0.00004002143,0.00001557559],"domain_scores_gemma":[0.9998342,0.00008723752,0.00002293234,0.000004312378,0.00003989361,0.00001140013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007755397,0.00005918846,0.0002902031,0.02156315,0.00008213305,0.0003433112,0.00009727901,0.0005404103,0.002786049,0.005260564,0.02013677,0.9487634],"study_design_scores_gemma":[0.00001561757,0.0001538003,0.00145374,0.005910442,0.0001472124,0.002315336,0.00009276632,0.0001602433,0.001041461,0.003177102,0.9855112,0.00002105398],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002233766,0.9982775,0.00010983,0.0002417715,0.0001006317,0.000004336087,0.00002545943,0.000005479373,0.001011651],"genre_scores_gemma":[0.001238926,0.9980683,0.0001111304,0.00013089,0.00007453289,0.000005108317,0.00003333075,8.252154e-7,0.0003370361],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002741483,"threshold_uncertainty_score":0.009171188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09864573449559158,"score_gpt":0.4171984688543284,"score_spread":0.3185527343587369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}