{"id":"W3127175217","doi":"10.1161/jaha.120.018756","title":"Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages","year":2021,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta; Université de Montréal; Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Neuraminidase; Foam cell; Sialic acid; Apolipoprotein E; Apolipoprotein B; Macrophage; Glycoprotein; Cholesterol; Chemistry; LDL receptor; Receptor; Fatty acid; Glycan; Internal medicine; Biochemistry; Lipoprotein; Endocrinology; Biology; Disease; In vitro; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905612,0.0004804218,0.0002543857,0.0001966617,0.000118552,0.0001914282,0.0001899395,0.0003446182,0.001014944],"category_scores_gemma":[0.0001305426,0.0001447137,0.0004417205,0.00008811997,0.0002481702,0.0001310652,0.0002129424,0.0004957859,0.0002641615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002671528,"about_ca_system_score_gemma":0.0001669005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004296786,"about_ca_topic_score_gemma":0.0005129654,"domain_scores_codex":[0.999885,0.00001935443,0.000009847806,0.00001801854,0.00002539663,0.00004242169],"domain_scores_gemma":[0.9998798,0.00001867089,0.00004894402,0.00001175,0.00001170251,0.00002910548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002522321,0.00003067317,0.0003152868,0.00003139335,0.000006299247,0.0000441345,0.00001009065,0.00002454572,0.9986696,0.00005273958,0.00001795015,0.0005449725],"study_design_scores_gemma":[0.00004328154,0.0008882169,0.007324674,0.000009413313,0.00003009188,0.0002250767,0.00003063378,0.0002151919,0.990123,0.0000715408,0.00103395,0.000004936178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963218,0.001140445,0.001518746,0.00006782579,0.00002148254,0.00003420609,0.0001322776,0.000044834,0.0007183692],"genre_scores_gemma":[0.9935953,0.001454624,0.002486064,0.0001097628,0.00001788056,0.00007080306,0.0002938929,0.00001433032,0.001957401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001014944,"threshold_uncertainty_score":0.003395319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007471833037643174,"score_gpt":0.221906216160857,"score_spread":0.2144343831232138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}