{"id":"W3127175217","doi":"10.1161/jaha.120.018756","title":"Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages","year":2021,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta; Université de Montréal; Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Neuraminidase; Foam cell; Sialic acid; Apolipoprotein E; Apolipoprotein B; Macrophage; Glycoprotein; Cholesterol; Chemistry; LDL receptor; Receptor; Fatty acid; Glycan; Internal medicine; Biochemistry; Lipoprotein; Endocrinology; Biology; Disease; In vitro; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006186086,0.0001013833,0.0003886299,0.00002357977,0.0002556692,0.00003698453,0.00006119463,0.00008232801,0.00001770726],"category_scores_gemma":[0.0005876062,0.00007064792,0.00009622637,0.0001352883,0.000124116,0.00006381583,0.00005577538,0.0002733717,0.000001304458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009413592,"about_ca_system_score_gemma":0.000045324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002966871,"about_ca_topic_score_gemma":0.00002841257,"domain_scores_codex":[0.9986352,0.0007407599,0.0002682826,0.0001271546,0.00004715356,0.0001814457],"domain_scores_gemma":[0.998786,0.0004081148,0.0005725882,0.00008517235,0.0001257,0.00002239717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004166058,0.00003172307,0.2658384,0.000002631651,0.00009586356,3.278073e-7,0.0001538981,2.631454e-7,0.7249526,6.452736e-7,0.003077115,0.005804856],"study_design_scores_gemma":[0.0005631367,0.0002395268,0.7032176,0.00003787071,0.00006404073,0.0002035403,0.0004243541,0.000003020875,0.2898099,0.00003554005,0.005307662,0.00009378705],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945434,0.002984487,0.00001562188,0.002152219,0.000203377,0.00005585572,0.00002865603,0.000006860428,0.000009503923],"genre_scores_gemma":[0.9981768,0.0006845429,0.00007843484,0.0007163192,0.00005384245,0.00000132115,0.000003266859,0.000008893817,0.0002765926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4373792,"threshold_uncertainty_score":0.2880938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007471833037643174,"score_gpt":0.221906216160857,"score_spread":0.2144343831232138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}