{"id":"W3127215208","doi":"10.1172/jci140105","title":"RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University; Hôpital Maisonneuve-Rosemont; Toronto General Hospital; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Ministero dello Sviluppo Economico; National Cancer Institute; University of Toronto; Cancer Research UK; Centres de Recerca de Catalunya; Government of Canada; Government of Ontario; Generalitat de Catalunya; Ministère du Développement Économique, de l’Innovation et de l’Exportation; European Regional Development Fund; European Commission; U.S. Department of Defense; Breast Cancer Research Foundation; Princess Margaret Cancer Foundation; Genome Canada; Fondation du cancer du sein du Québec; National Institutes of Health; Terry Fox Foundation; Ovarian Cancer Research Fund","keywords":"Genome instability; Biology; DNA damage; Carcinogenesis; DNA repair; Cancer research; Mitotic catastrophe; Genetics; Mutation; Mutagenesis; Cancer; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353342,0.0003678333,0.0002541886,0.0003255997,0.0001385994,0.0002184234,0.0002103565,0.0003314698,0.001058228],"category_scores_gemma":[0.0001368127,0.0001711319,0.0001873217,0.00008306101,0.0002149547,0.0001344768,0.000166443,0.0003548033,0.0005278979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914595,"about_ca_system_score_gemma":0.0001655939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005250355,"about_ca_topic_score_gemma":0.0008079511,"domain_scores_codex":[0.9998848,0.00001978047,0.00001332835,0.00002909908,0.00002687152,0.00002614628],"domain_scores_gemma":[0.999806,0.00002045915,0.00008262423,0.00001364348,0.00001409641,0.0000632699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000905001,0.00001848541,0.0001552813,0.00001271888,0.0000019135,0.00005880451,0.00000647771,0.00003077185,0.9990698,0.00002723943,0.00001876981,0.0005092967],"study_design_scores_gemma":[0.00002391871,0.000284135,0.007251675,0.000006180935,0.000009627604,0.0006901867,0.00002755135,0.001202084,0.9888536,0.00005242643,0.001591582,0.000006971304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967037,0.001013005,0.001130134,0.00006727928,0.00001483503,0.00001799492,0.000189816,0.000158729,0.0007045276],"genre_scores_gemma":[0.995989,0.00039495,0.001312284,0.0000299868,0.00000605573,0.00002489851,0.0002388977,0.00003554255,0.001968289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058228,"threshold_uncertainty_score":0.003540099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05132680537967718,"score_gpt":0.3250169134330457,"score_spread":0.2736901080533686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}