{"id":"W3127215208","doi":"10.1172/jci140105","title":"RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University; Hôpital Maisonneuve-Rosemont; Toronto General Hospital; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Ministero dello Sviluppo Economico; National Cancer Institute; University of Toronto; Cancer Research UK; Centres de Recerca de Catalunya; Government of Canada; Government of Ontario; Generalitat de Catalunya; Ministère du Développement Économique, de l’Innovation et de l’Exportation; European Regional Development Fund; European Commission; U.S. Department of Defense; Breast Cancer Research Foundation; Princess Margaret Cancer Foundation; Genome Canada; Fondation du cancer du sein du Québec; National Institutes of Health; Terry Fox Foundation; Ovarian Cancer Research Fund","keywords":"Genome instability; Biology; DNA damage; Carcinogenesis; DNA repair; Cancer research; Mitotic catastrophe; Genetics; Mutation; Mutagenesis; Cancer; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002256037,0.00008121636,0.000233855,0.00003880038,0.00002818098,0.00002165368,0.00007906781,0.0001681642,0.00001234301],"category_scores_gemma":[0.002581666,0.00007599072,0.0001071198,0.00009570322,0.0001419197,0.00001104292,0.00007581697,0.0002167324,0.000001519918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002871028,"about_ca_system_score_gemma":0.0003279924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006070643,"about_ca_topic_score_gemma":0.00003114149,"domain_scores_codex":[0.9981416,0.0003748547,0.0009819568,0.0002217535,0.0001613168,0.0001185163],"domain_scores_gemma":[0.9989122,0.00008475327,0.0004460623,0.0001895818,0.0002324263,0.0001349657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118535,0.0001002746,0.05707923,0.00002130046,0.00002067055,0.00001788473,0.00005315915,0.0002315822,0.939816,0.0002491137,0.0002071548,0.002091796],"study_design_scores_gemma":[0.001199387,0.0005650372,0.3136343,0.00009524424,0.00002839989,0.0001141054,0.0001718341,0.001390478,0.6748677,0.006845811,0.000948329,0.000139324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979383,0.0007327574,0.0002322741,0.0007036577,0.0002445918,0.00006578999,0.000002055415,0.000003146356,0.00007743833],"genre_scores_gemma":[0.9946357,0.0001981015,0.004522278,0.0003355052,0.000209658,0.000001174798,0.00001328659,0.000008583749,0.00007568931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2649482,"threshold_uncertainty_score":0.3098812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05132680537967718,"score_gpt":0.3250169134330457,"score_spread":0.2736901080533686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}