{"id":"W3127235909","doi":"10.1021/acs.jproteome.0c00775","title":"Confident Identification of Citrullination and Carbamylation Assisted by Peptide Retention Time Prediction","year":2021,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deamidation; Chemistry; Citrullination; Chromatography; Peptide; Mass spectrometry; Hydrophilic interaction chromatography; Citrulline; Arginine; Asparagine; Hydrogen–deuterium exchange; High-performance liquid chromatography; Biochemistry; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001436287,0.001043651,0.000666566,0.001088261,0.0002898769,0.001084868,0.0006414721,0.001281839,0.0008223797],"category_scores_gemma":[0.003808601,0.0003331669,0.0005292791,0.0007282107,0.0004661968,0.001049146,0.0006402511,0.0009906093,0.0008690482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002915029,"about_ca_system_score_gemma":0.0004561541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258397,"about_ca_topic_score_gemma":0.0007151418,"domain_scores_codex":[0.9987393,0.0002002644,0.00009721984,0.0004504777,0.0004158465,0.000096841],"domain_scores_gemma":[0.9979427,0.0006412911,0.0005912933,0.0002252603,0.0004683925,0.000131096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003455705,0.00002558427,0.002496127,0.0001325877,0.00003086111,0.0001540315,0.00004376946,0.0002564159,0.9851514,0.0001017618,0.00007918706,0.01118258],"study_design_scores_gemma":[0.00002459901,0.0003543763,0.02046315,0.00003588027,0.00009627669,0.001626243,0.00006862478,0.01771521,0.9567326,0.0003310247,0.002484073,0.00006790851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8614058,0.006030819,0.1276308,0.0002052858,0.0001417466,0.0001397226,0.001245167,0.0007025069,0.002498046],"genre_scores_gemma":[0.8276438,0.002739889,0.1652313,0.0002804089,0.00007131373,0.0001489599,0.001791739,0.0002088628,0.001883707],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001436287,"threshold_uncertainty_score":0.007595956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03925654251946654,"score_gpt":0.3521815087747927,"score_spread":0.3129249662553261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}