{"id":"W3127281995","doi":"10.3390/cells10020301","title":"Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Österreichische Forschungsförderungsgesellschaft; U.S. Department of Veterans Affairs","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Eukaryotic translation; Neuroblastoma; Eukaryotic initiation factor; Initiation factor; Translation (biology); Biology; Protein kinase B; eIF4A; Heterotrimeric G protein; Apoptosis; Signal transduction; Cell biology; Cell culture; Messenger RNA; Genetics; Gene; G protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003604141,0.0001158907,0.000169791,0.0001384199,0.00003312479,0.00002406809,0.00003795907,0.00005977061,0.0004494995],"category_scores_gemma":[0.00003607736,0.0001121431,0.00007622889,0.0002883183,0.00002246904,0.0001178372,0.00001803262,0.0001814167,0.0001769755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005324987,"about_ca_system_score_gemma":0.0001707219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001010234,"about_ca_topic_score_gemma":0.00001880218,"domain_scores_codex":[0.9989458,0.00005355607,0.0001915549,0.0002646636,0.000281724,0.000262711],"domain_scores_gemma":[0.9995406,0.00004991523,0.00003193564,0.0001673111,0.00007029947,0.0001399048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002284979,0.0007961743,0.002614844,0.00008009941,0.00003013074,0.001683684,0.0001596279,0.0001468783,0.9911235,0.00001283485,0.0001154519,0.0030083],"study_design_scores_gemma":[0.00611207,0.000464238,0.2663883,0.00008091133,0.00003758327,0.0001669289,0.00003471355,0.004190636,0.7216775,0.00007735498,0.0006206027,0.000149103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959149,0.00008195784,0.001386535,0.0006353223,0.0001875108,0.000307805,0.00003551897,0.00003967403,0.001410711],"genre_scores_gemma":[0.9977413,0.00003251493,0.001277026,0.0002251996,0.00006957216,0.00001099932,0.00009011097,0.00002244313,0.0005308049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2694459,"threshold_uncertainty_score":0.4921705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03209340987280172,"score_gpt":0.2800892136393037,"score_spread":0.247995803766502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}