{"id":"W3127281995","doi":"10.3390/cells10020301","title":"Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Österreichische Forschungsförderungsgesellschaft; U.S. Department of Veterans Affairs","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Eukaryotic translation; Neuroblastoma; Eukaryotic initiation factor; Initiation factor; Translation (biology); Biology; Protein kinase B; eIF4A; Heterotrimeric G protein; Apoptosis; Signal transduction; Cell biology; Cell culture; Messenger RNA; Genetics; Gene; G protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139464,0.0003606425,0.0005005396,0.0002644145,0.0001495368,0.0003027447,0.0002684685,0.0003913456,0.001275561],"category_scores_gemma":[0.00008337701,0.0001074397,0.0002644248,0.0002289446,0.0001318828,0.0002364179,0.0001887776,0.0005656363,0.0004983608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352651,"about_ca_system_score_gemma":0.0002420045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003716677,"about_ca_topic_score_gemma":0.001095985,"domain_scores_codex":[0.9999542,0.000006170972,0.000004042567,0.00001114916,0.0000128585,0.00001156986],"domain_scores_gemma":[0.9999719,0.000004453871,0.000008241997,0.000002264775,0.000005335606,0.000007835401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008071264,0.0001801689,0.001389806,0.001327381,0.00004921332,0.0007653013,0.00006178062,0.0005006797,0.9069949,0.0007878033,0.001633568,0.0855023],"study_design_scores_gemma":[0.0003622753,0.003808959,0.01667083,0.0003843835,0.0003633603,0.005234782,0.0001841292,0.002091706,0.7885554,0.001005968,0.1812824,0.00005588613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5391607,0.4321325,0.01167933,0.002446234,0.0008035328,0.0002624207,0.001657241,0.0005612525,0.0112967],"genre_scores_gemma":[0.82262,0.1527464,0.01192008,0.0007268507,0.0002673639,0.0002430158,0.002643625,0.00005063612,0.008782133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275561,"threshold_uncertainty_score":0.004267216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03209340987280172,"score_gpt":0.2800892136393037,"score_spread":0.247995803766502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}