{"id":"W3127311419","doi":"10.1002/mds.28519","title":"Brain Damage and Gene Expression Across Hereditary Spastic Paraplegia Subtypes","year":2021,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Hereditary spastic paraplegia; Cerebellum; White matter; Pathology; Neuroscience; Atrophy; Biology; Medicine; Gene; Genetics; Phenotype; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001552364,0.0002867266,0.0002398164,0.00004234416,0.0003204923,0.0001000183,0.0002791437,0.0001081788,0.0006301563],"category_scores_gemma":[0.0008649771,0.0002675053,0.000085242,0.0003302799,0.0002737941,0.0002820825,0.0003916808,0.0002556287,0.00006095606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002224786,"about_ca_system_score_gemma":0.00003716633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000405368,"about_ca_topic_score_gemma":0.0001840588,"domain_scores_codex":[0.9974299,0.0002748274,0.000295408,0.000915438,0.0004329792,0.000651461],"domain_scores_gemma":[0.9988129,0.0004659598,0.00005378949,0.0004492563,0.0000228142,0.0001953498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001020576,0.0005128788,0.01287042,0.00006043476,0.00001236128,0.0005340335,0.0005414775,0.0004090486,0.952027,0.0004611609,0.02806912,0.004400047],"study_design_scores_gemma":[0.004440011,0.0008145118,0.1441552,0.00007234493,0.00003369738,0.00001319525,0.002659093,0.00309832,0.7413965,0.07744071,0.02435598,0.001520478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832855,0.0003167813,0.0005978678,0.01323324,0.0005645221,0.0003016417,0.00008931094,0.000156306,0.001454782],"genre_scores_gemma":[0.9611495,0.0003399652,0.0002169943,0.03752417,0.00007350133,0.00004871443,0.00002990113,0.00004002433,0.0005772042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2106305,"threshold_uncertainty_score":0.9999777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029166962296234,"score_gpt":0.2655924063095929,"score_spread":0.2453007366866306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}