{"id":"W3127330586","doi":"10.2147/ott.s291086","title":"Combination Therapy with iRGD-antiCD3 and PD-1 Blockade Enhances Antitumor Potency of Cord Blood-Derived T Cells","year":2021,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"In vivo; Cancer research; Immune system; Tumor microenvironment; T cell; Immunotherapy; In vitro; Cytotoxic T cell; CD3; Antibody; Chemistry; Antigen; CD8; Medicine; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322439,0.0001813341,0.0004108245,0.00006629896,0.0001276024,0.00002994192,0.00005673238,0.00006257454,0.0002515994],"category_scores_gemma":[0.000008398728,0.0001172199,0.00005752023,0.0001549063,0.0002483716,0.00007023456,0.00002789155,0.0001540338,0.00000262447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004912553,"about_ca_system_score_gemma":0.0001136194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002427402,"about_ca_topic_score_gemma":0.00002181291,"domain_scores_codex":[0.9988572,0.00006138506,0.0002175459,0.0002978077,0.0003231898,0.000242842],"domain_scores_gemma":[0.9992999,0.00008659684,0.00008881168,0.0001624374,0.0002275552,0.0001346895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001640799,0.000742343,0.03384209,0.000103381,0.0002797717,0.0001746072,0.0003898423,2.452913e-7,0.9284567,0.0005552442,0.0000567573,0.03375819],"study_design_scores_gemma":[0.004637168,0.00300005,0.1062764,0.0001266429,0.00003468562,0.000161895,0.000117999,0.0000511524,0.872121,0.0004080439,0.01288584,0.0001791465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752061,0.02126646,0.00001965032,0.001690816,0.0000687713,0.000268648,0.00001566606,0.00001648546,0.001447406],"genre_scores_gemma":[0.8900688,0.1063518,0.0009985373,0.0003083777,0.0000804587,0.00000787849,0.00002334259,0.00001815076,0.002142624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0851373,"threshold_uncertainty_score":0.4780088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948952803681661,"score_gpt":0.2845316611152413,"score_spread":0.2650421330784247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}