{"id":"W3127344315","doi":"10.1021/acsmedchemlett.0c00386","title":"Design and Structure–Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin","year":2021,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Narodowe Centrum Nauki","keywords":"Furin; Hemagglutinin (influenza); Peptide; Structure–activity relationship; Amino acid residue; Amino acid; Biology; Virology; Enzyme; Influenza A virus; Peptide sequence; Computational biology; Biochemistry; Chemistry; Virus; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002438354,0.0002338066,0.0004807815,0.00004649951,0.0001089979,0.0000140421,0.00009119976,0.0001398114,0.00009566039],"category_scores_gemma":[0.001527846,0.0002088185,0.00006230077,0.0002206741,0.0003600511,0.00008159582,0.00014815,0.0005943381,0.000003329965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287498,"about_ca_system_score_gemma":0.0002320144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008716095,"about_ca_topic_score_gemma":0.000002218187,"domain_scores_codex":[0.9981033,0.0001093087,0.0003553128,0.0004192825,0.0006744592,0.000338378],"domain_scores_gemma":[0.9983813,0.0006367753,0.000156364,0.0003937623,0.0002106211,0.0002212419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005450578,0.0000527632,0.02381718,0.000325821,0.0001910802,0.0002977095,0.0007868094,0.00002423692,0.9722561,0.000002037354,0.0005742747,0.001126951],"study_design_scores_gemma":[0.002198524,0.00004490616,0.1031478,0.0003080084,0.0001534055,0.00009423126,0.0003630078,0.00004763452,0.8932688,0.00006134438,0.0001608679,0.0001515316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993126,0.001530711,0.0007754422,0.004068957,0.0000496224,0.0002231495,0.00002897998,0.00003535961,0.0001617796],"genre_scores_gemma":[0.9938738,0.00004235861,0.00374177,0.001960465,0.0002812124,0.000015192,0.00002659535,0.00002299933,0.00003557626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07933061,"threshold_uncertainty_score":0.8515372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06746586713571333,"score_gpt":0.3268568537191113,"score_spread":0.2593909865833979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}