{"id":"W3127344315","doi":"10.1021/acsmedchemlett.0c00386","title":"Design and Structure–Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin","year":2021,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Narodowe Centrum Nauki","keywords":"Furin; Hemagglutinin (influenza); Peptide; Structure–activity relationship; Amino acid residue; Amino acid; Biology; Virology; Enzyme; Influenza A virus; Peptide sequence; Computational biology; Biochemistry; Chemistry; Virus; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161474,0.0002935651,0.0002998006,0.0001745545,0.0001234484,0.0002264918,0.0002526173,0.0002236783,0.0005643385],"category_scores_gemma":[0.0001006655,0.0001237188,0.0001879524,0.0001557235,0.0001031872,0.0001440733,0.0001118439,0.0003739544,0.0002304382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002439038,"about_ca_system_score_gemma":0.0001782351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005214745,"about_ca_topic_score_gemma":0.0007973452,"domain_scores_codex":[0.9999357,0.00001023324,0.000005798284,0.00001336589,0.00001676204,0.00001801008],"domain_scores_gemma":[0.9999609,0.000005116403,0.000008368896,0.000002522833,0.000007374791,0.00001577127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003399978,0.0002206588,0.0002334343,0.00004762115,0.00001719806,0.00008322188,0.00001253289,0.001308138,0.9938912,0.0001166956,0.00007111397,0.003658121],"study_design_scores_gemma":[0.0001655084,0.002894767,0.00208317,0.00000850891,0.00005664106,0.0002748821,0.00001365343,0.006390648,0.9850833,0.0000399263,0.002974315,0.00001475902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912088,0.002336357,0.004194806,0.00008413931,0.00002049618,0.0001262809,0.0002263105,0.00003024405,0.001772659],"genre_scores_gemma":[0.9922338,0.001355101,0.004670383,0.00005636994,0.000008696788,0.00003904155,0.0004479616,0.000008337625,0.001180274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005643385,"threshold_uncertainty_score":0.001887918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06746586713571333,"score_gpt":0.3268568537191113,"score_spread":0.2593909865833979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}