{"id":"W3127348240","doi":"10.1038/s41398-020-01147-z","title":"Combined effects of genotype and childhood adversity shape variability of DNA methylation across age","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Mental Health; Laureate Institute for Brain Research, University of Tulsa; Greenwich Biosciences; Sunovion; H. Lundbeck A/S; Allergan; Emil Aaltosen Säätiö; Signe ja Ane Gyllenbergin Säätiö; British Heart Foundation; Clinical Science Research and Development; Vistagen Therapeutics; ACADIA Pharmaceuticals; Jazz Pharmaceuticals; Wellcome Trust; Samfundet Folkhälsan; Helsingin Yliopisto; American Foundation for Suicide Prevention; Celgene; National Institutes of Health; Novo Nordisk; OPKO Health; BrainsWay; Folkhälsanin Tutkimussäätiö; Sage Therapeutics; Finska Läkaresällskapet; Bundesministerium für Bildung und Forschung; American Psychiatric Publishing","keywords":"Genotype; DNA methylation; Psychology; Genetics; Methylation; Schizophrenia (object-oriented programming); Clinical psychology; Psychiatry; Medicine; Developmental psychology; DNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006690277,0.0003015061,0.0003678568,0.0005049278,0.0002279516,0.0005348733,0.0003253332,0.0003295926,0.001910139],"category_scores_gemma":[0.001962318,0.0002941769,0.0005543507,0.0005156939,0.0003559137,0.0002337232,0.0005219061,0.0003843111,0.0002856614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200463,"about_ca_system_score_gemma":0.0002304606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00723711,"about_ca_topic_score_gemma":0.01184286,"domain_scores_codex":[0.9994235,0.0001725884,0.00002462918,0.0002722807,0.00005137324,0.00005569582],"domain_scores_gemma":[0.9988199,0.0004207182,0.0003044867,0.000274262,0.00009629439,0.00008430515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003356842,0.00001607869,0.9668187,0.0000445141,0.0007299373,0.0001097019,0.0004310797,0.0007715118,0.02000276,0.0002284622,0.0002444254,0.01026717],"study_design_scores_gemma":[0.000001556383,0.00004828514,0.9978682,0.000006892003,0.00008202095,0.000113713,0.00008420892,0.0004373414,0.0008275413,0.0002147014,0.0003102668,0.000005360745],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938976,0.0006191549,0.003037496,0.00005584327,0.00000923096,0.00000692821,0.001597167,0.00003792581,0.0007385994],"genre_scores_gemma":[0.9977805,0.0001923199,0.0009640983,0.00003632801,0.000004306645,0.000009910163,0.0006228484,0.00002573017,0.0003640065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00723711,"threshold_uncertainty_score":0.01438999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005878456282975883,"score_gpt":0.2496793376779756,"score_spread":0.2438008813949997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}