{"id":"W3127348240","doi":"10.1038/s41398-020-01147-z","title":"Combined effects of genotype and childhood adversity shape variability of DNA methylation across age","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Mental Health; Laureate Institute for Brain Research, University of Tulsa; Greenwich Biosciences; Sunovion; H. Lundbeck A/S; Allergan; Emil Aaltosen Säätiö; Signe ja Ane Gyllenbergin Säätiö; British Heart Foundation; Clinical Science Research and Development; Vistagen Therapeutics; ACADIA Pharmaceuticals; Jazz Pharmaceuticals; Wellcome Trust; Samfundet Folkhälsan; Helsingin Yliopisto; American Foundation for Suicide Prevention; Celgene; National Institutes of Health; Novo Nordisk; OPKO Health; BrainsWay; Folkhälsanin Tutkimussäätiö; Sage Therapeutics; Finska Läkaresällskapet; Bundesministerium für Bildung und Forschung; American Psychiatric Publishing","keywords":"Genotype; DNA methylation; Psychology; Genetics; Methylation; Schizophrenia (object-oriented programming); Clinical psychology; Psychiatry; Medicine; Developmental psychology; DNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002373365,0.00009391364,0.000150946,0.00001826785,0.00005162419,0.000004565649,0.00005667573,0.0001320622,0.0000181996],"category_scores_gemma":[0.0000621024,0.0001028476,0.00008516356,0.0001036957,0.00006832362,0.000005068349,0.00002503419,0.00005465425,4.122187e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002568107,"about_ca_system_score_gemma":0.0001025728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005128049,"about_ca_topic_score_gemma":0.00002748811,"domain_scores_codex":[0.9991815,0.0001031179,0.0002432755,0.0002342026,0.0001406566,0.00009722773],"domain_scores_gemma":[0.9994869,0.00005684256,0.0001017965,0.0001860247,0.0001274648,0.00004100495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001331279,0.0003304162,0.1890561,0.0002575069,0.0001186624,4.937722e-7,0.000285428,0.0001976704,0.8032922,0.001730637,0.000008705402,0.004589094],"study_design_scores_gemma":[0.001019612,0.0001279541,0.7724757,0.00001460964,0.00003736301,4.802581e-7,0.00001491847,0.00008300057,0.2185435,0.007474055,0.0001187242,0.00009005677],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916387,0.002096053,0.005321011,0.0001407782,0.0001962633,0.0001411934,0.00005463587,0.000004348224,0.0004070002],"genre_scores_gemma":[0.9930267,0.0001293832,0.006439295,0.00002784069,0.00006402963,0.000002017523,0.0002831479,0.000008709439,0.00001889569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5847487,"threshold_uncertainty_score":0.4194002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005878456282975883,"score_gpt":0.2496793376779756,"score_spread":0.2438008813949997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}