{"id":"W3127348774","doi":"10.1002/da.23135","title":"Treatment‐resistant major depressive disorder: Canadian expert consensus on definition and assessment","year":2021,"lang":"en","type":"review","venue":"Depression and Anxiety","topic":"Treatment of Major Depression","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University; Ontario Shores Centre for Mental Health Sciences; University of British Columbia; McGill University; University of Calgary; Western University","funders":"","keywords":"Delphi method; Psychology; Treatment-resistant depression; Grading (engineering); Major depressive disorder; Medicine; Psychiatry; Clinical psychology; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008636157,0.0008350039,0.001907042,0.0003138698,0.0004714938,0.0001208113,0.00008376182,0.0006296305,0.0001868486],"category_scores_gemma":[0.00007117354,0.0005519149,0.0004034797,0.0001729811,0.0001226717,0.00004851308,0.0001060487,0.0004765731,0.00001720579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00045335,"about_ca_system_score_gemma":0.0008650145,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006898194,"about_ca_topic_score_gemma":0.002763882,"domain_scores_codex":[0.9970556,0.0003001887,0.0005529017,0.001191838,0.0003884168,0.0005110337],"domain_scores_gemma":[0.997784,0.0002819368,0.0002794343,0.0007046855,0.00007373026,0.0008762471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006167027,0.0003483392,0.00152336,0.001502795,0.0003565513,0.0007104847,0.00005950998,6.451891e-8,0.00002231067,0.0001653578,0.00199589,0.9932536],"study_design_scores_gemma":[0.003357027,0.0003900218,0.001300134,0.01669407,0.001592671,0.0009066851,0.00009566218,0.00001182715,0.00003293492,0.00001729876,0.9750985,0.0005031841],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001007004,0.9885387,0.000003188546,0.0004380381,0.0001928021,0.001397887,0.0003731531,0.00009123495,0.007958036],"genre_scores_gemma":[0.00231458,0.9934936,0.001123371,0.0002334944,0.0001453988,0.0004330623,0.001400204,0.0001072806,0.0007489672],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9927505,"threshold_uncertainty_score":0.999715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04914504291681591,"score_gpt":0.3454780810331142,"score_spread":0.2963330381162982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}