{"id":"W3127445432","doi":"10.1101/2021.01.27.428487","title":"Associations of psychiatric disease and aging on <i>FKBP5</i> expression converge on cortical supragranular neurons","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression; National Health and Medical Research Council; Fondation Brain Canada; Canada First Research Excellence Fund; International Brain Research Organization; Rebecca L. Cooper Medical Research Foundation; Victorian Brain Bank; Alexander von Humboldt-Stiftung","keywords":"FKBP5; Neuroscience; Schizophrenia (object-oriented programming); Biology; Prefrontal cortex; Disease; Medicine; Psychiatry; Genetics; Internal medicine; Gene; Cognition; Glucocorticoid receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162055,0.0001945008,0.0001895223,0.0002481572,0.0002164832,0.0002299112,0.0001213219,0.000144512,0.00186756],"category_scores_gemma":[0.0001538674,0.0001022256,0.0001665595,0.00011526,0.0002357882,0.0001259627,0.0002356403,0.0002070949,0.000258015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257103,"about_ca_system_score_gemma":0.0001407671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004091179,"about_ca_topic_score_gemma":0.008425402,"domain_scores_codex":[0.999921,0.0000075288,0.0000052165,0.00003051605,0.0000142246,0.00002153267],"domain_scores_gemma":[0.9998728,0.00001347599,0.00004990215,0.00001700691,0.00002366825,0.00002302946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006886314,0.00002347982,0.05610143,0.00009119226,0.0000863909,0.0002053445,0.0001463168,0.0001506772,0.9326772,0.0001667851,0.0004128685,0.009249681],"study_design_scores_gemma":[0.000005442027,0.00009456671,0.9600502,0.00001154327,0.0000371944,0.0003108243,0.0001412156,0.0002508749,0.03802514,0.0001391607,0.0009272865,0.000006502522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962606,0.0005755834,0.001360074,0.00006268797,0.000007634868,0.000007429886,0.0006824631,0.00003376613,0.001009832],"genre_scores_gemma":[0.9981261,0.0001794816,0.0005707172,0.00004458173,0.000003112474,0.0000099022,0.0003262355,0.000008429848,0.0007315357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004091179,"threshold_uncertainty_score":0.008134723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090341059370589,"score_gpt":0.2497210215076833,"score_spread":0.2288176109139774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}