{"id":"W3127454388","doi":"10.1158/1078-0432.ccr-20-3260","title":"Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"Medical Research Council; Imperial Experimental Cancer Medicine Centre; Royal Marsden NHS Foundation Trust; Department of Health and Social Care; National Institute for Health and Care Research; Cancer Council NSW; Cancer Research UK; Academy of Medical Sciences; Prostate Cancer Canada; Prostate Cancer Foundation; Movember Foundation; Prostate Cancer UK; U.S. Department of Defense","keywords":"Enzalutamide; Prostate cancer; Cancer; Medicine; Prostate; Oncology; Resistance (ecology); Internal medicine; Biology; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500077,0.0003349316,0.0002763217,0.0002903994,0.0001711929,0.0004335788,0.0001842021,0.0001576708,0.001174941],"category_scores_gemma":[0.0001238227,0.0001326384,0.0002371907,0.0002989207,0.000187663,0.0001292526,0.000166266,0.0006141353,0.0002872125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691975,"about_ca_system_score_gemma":0.0003335563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008478364,"about_ca_topic_score_gemma":0.00202865,"domain_scores_codex":[0.9998589,0.00001885079,0.00001713685,0.00002546414,0.00005254854,0.0000270848],"domain_scores_gemma":[0.9998803,0.00001619761,0.00004063005,0.00001736912,0.00002082542,0.00002464687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001789594,0.00007812581,0.002236727,0.00006786834,0.0000163031,0.0001666166,0.00001350971,0.0001315747,0.994218,0.00007878994,0.00008837892,0.002725017],"study_design_scores_gemma":[0.00006133345,0.0009631996,0.03147426,0.00001248719,0.00007356119,0.002858249,0.00006277493,0.001296598,0.9596661,0.00007725199,0.003443096,0.00001125053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936085,0.003021738,0.001420187,0.00009169188,0.00001514632,0.00003864031,0.000416165,0.0001169108,0.001270936],"genre_scores_gemma":[0.9965502,0.00101307,0.000778384,0.00003792048,0.000003735101,0.00002078799,0.0005994945,0.000008875954,0.0009875852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174941,"threshold_uncertainty_score":0.003930509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1367756784711342,"score_gpt":0.4662400923479494,"score_spread":0.3294644138768151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}