{"id":"W3127466289","doi":"10.1101/2021.01.28.428736","title":"Resurrection of a viral internal ribosome entry site from a 700 year old ancient Northwest Territories cripavirus","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internal ribosome entry site; Biology; Ribosome; Genetics; Eukaryotic translation; Shine-Dalgarno sequence; Start codon; Virology; Translation (biology); RNA; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243855,0.000193589,0.0002059473,0.0001880296,0.0002311403,0.0003197534,0.0001828381,0.0002509969,0.0007413551],"category_scores_gemma":[0.0001842437,0.000137149,0.000287898,0.0001053904,0.0002100553,0.0001187909,0.0002354391,0.0008631952,0.0004013589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006659835,"about_ca_system_score_gemma":0.0002957241,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002881554,"about_ca_topic_score_gemma":0.004649435,"domain_scores_codex":[0.9999272,0.000008342899,0.000004041548,0.00002256147,0.00002273003,0.00001508245],"domain_scores_gemma":[0.9999014,0.00001927815,0.00002060593,0.0000128372,0.00001702303,0.0000288469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003864295,0.000006850678,0.0006574368,0.00001454757,0.000004014127,0.0001228065,0.00004688787,0.00005527982,0.9978071,0.0001667556,0.00002950254,0.001050143],"study_design_scores_gemma":[0.00002017221,0.000306139,0.03814688,0.0000263919,0.00003965772,0.001686244,0.0002727527,0.003525897,0.9455994,0.000152389,0.01020242,0.00002169602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951603,0.0002194117,0.00313268,0.00004098604,0.00002217341,0.00001612779,0.0001641045,0.00003643977,0.001207845],"genre_scores_gemma":[0.9890098,0.0001934161,0.005995907,0.00009796505,0.000009290996,0.00001828587,0.0009499428,0.00004240319,0.003683103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9971185,"threshold_uncertainty_score":0.005729496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522973271094461,"score_gpt":0.2578207605400523,"score_spread":0.2425910278291077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}