{"id":"W3127501779","doi":"10.1016/j.biopsych.2021.01.015","title":"Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; National Institute of Environmental Health Sciences; U.S. Department of Veterans Affairs","keywords":"DNA methylation; Cognition; Methylation; Cognitive decline; Biology; Genetics; DNA; Neuroscience; Medicine; Dementia; Internal medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003029547,0.0001450151,0.0001600342,0.0000322223,0.00004546023,0.00001826132,0.00007876678,0.0002898881,0.00005204223],"category_scores_gemma":[0.000527785,0.000113242,0.00006667694,0.0001808003,0.00004545723,0.000002693269,0.0000739889,0.0001210129,0.000005486472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001233071,"about_ca_system_score_gemma":0.00008834621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007505822,"about_ca_topic_score_gemma":0.0007317987,"domain_scores_codex":[0.9987768,0.0002526286,0.0002382173,0.0004132154,0.0001041463,0.0002150132],"domain_scores_gemma":[0.9994956,0.00007934768,0.00009880124,0.0001491435,0.0001149774,0.00006207912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001263224,0.0002725358,0.8957494,0.000005303255,0.00004576122,0.000008179079,0.00001376115,0.00002504971,0.1007546,0.0001929,0.00005590503,0.00275021],"study_design_scores_gemma":[0.001345653,0.0005730081,0.9535995,0.00004841826,0.00001254345,0.000002583105,0.00009407894,0.00002662521,0.04131322,0.001611556,0.001135714,0.0002370775],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919978,0.001621634,0.003966001,0.0009563181,0.000181107,0.0001340687,0.00004968324,0.00001422198,0.001079099],"genre_scores_gemma":[0.9965029,0.0002074236,0.0006075607,0.001023002,0.0001827289,0.00001660849,0.001297877,0.00001309688,0.0001487804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0594414,"threshold_uncertainty_score":0.4617874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222521880949018,"score_gpt":0.2907828952023745,"score_spread":0.2685576763928844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}