{"id":"W3127517011","doi":"10.1016/j.ynirp.2020.100002","title":"FDG-PET assessment of the locus coeruleus in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Neuroimage Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Medical Research Council; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Deutsche Forschungsgemeinschaft; University of Southern California; Wellcome Trust; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; Canadian Institutes of Health Research; Wellcome; University College London Hospitals NHS Foundation Trust; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense","keywords":"Locus coeruleus; Biomarker; Positron emission tomography; Standardized uptake value; In vivo; Pons; Nuclear medicine; Imaging biomarker; Internal medicine; Medicine; Neuroscience; Pathology; Magnetic resonance imaging; Oncology; Biology; Radiology; Central nervous system; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009471136,0.0002788321,0.0004570668,0.000655577,0.0001853033,0.0004787251,0.0003520956,0.000384015,0.0004545505],"category_scores_gemma":[0.0008030953,0.0001169051,0.0001258601,0.0003206976,0.0002954806,0.000234531,0.0001651402,0.0002159044,0.000131083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716994,"about_ca_system_score_gemma":0.0001390941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003299752,"about_ca_topic_score_gemma":0.00678113,"domain_scores_codex":[0.9997988,0.00006632516,0.00002390116,0.00003814601,0.00004752081,0.00002521547],"domain_scores_gemma":[0.9997388,0.00005665598,0.00006383601,0.00003438654,0.00007305905,0.00003323538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002523599,0.0002720347,0.5934392,0.000532485,0.0004123029,0.00252651,0.0005529111,0.0008567004,0.299631,0.0003223779,0.0005360923,0.09839471],"study_design_scores_gemma":[0.00004011593,0.0007218981,0.9779652,0.00005196361,0.0001293948,0.003492045,0.0002340228,0.001740463,0.0140573,0.000347723,0.001204673,0.00001525392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852892,0.009702767,0.003326752,0.00007238771,0.00001798878,0.00004519214,0.0001569712,0.00003007026,0.001358779],"genre_scores_gemma":[0.9955389,0.00162603,0.002209886,0.00003092387,0.00001188458,0.00001888951,0.0001273061,0.000005591806,0.0004305038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003299752,"threshold_uncertainty_score":0.0065611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03778429702201445,"score_gpt":0.3552380715350331,"score_spread":0.3174537745130186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}