{"id":"W3127517011","doi":"10.1016/j.ynirp.2020.100002","title":"FDG-PET assessment of the locus coeruleus in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Neuroimage Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Medical Research Council; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Deutsche Forschungsgemeinschaft; University of Southern California; Wellcome Trust; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; Canadian Institutes of Health Research; Wellcome; University College London Hospitals NHS Foundation Trust; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense","keywords":"Locus coeruleus; Biomarker; Positron emission tomography; Standardized uptake value; In vivo; Pons; Nuclear medicine; Imaging biomarker; Internal medicine; Medicine; Neuroscience; Pathology; Magnetic resonance imaging; Oncology; Biology; Radiology; Central nervous system; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001926029,0.0001828756,0.0003364442,0.00007515473,0.0000640393,0.0000246633,0.00008056701,0.00003219572,0.0002574004],"category_scores_gemma":[0.0002951604,0.0001304324,0.0002350421,0.0003989242,0.0001352745,0.00008840647,0.0001792697,0.0002884632,0.00000909861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006645158,"about_ca_system_score_gemma":0.001718677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008239615,"about_ca_topic_score_gemma":0.0000172236,"domain_scores_codex":[0.9975746,0.0001697849,0.0004799015,0.0004896161,0.0009286383,0.0003574732],"domain_scores_gemma":[0.9979439,0.00006590844,0.0001846485,0.001141032,0.0002389555,0.0004255404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008650109,0.00154424,0.8335018,0.00007106694,0.001280154,0.1604041,0.00001387666,0.00001443918,0.0009950412,0.00004106022,0.0009409358,0.001106768],"study_design_scores_gemma":[0.0009622713,0.00007773937,0.9922426,0.0001335033,0.0008062758,0.001527719,0.00001917018,0.00014477,0.00308244,0.0002102536,0.0006851736,0.0001080523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796348,0.00822073,0.000005280342,0.001615442,0.0002709228,0.0007689428,0.00003910834,0.00003939808,0.009405396],"genre_scores_gemma":[0.9990974,0.0001850389,0.0001465244,0.0002618558,0.00004682544,0.00004895974,0.00005685972,0.00003163793,0.0001248689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1588764,"threshold_uncertainty_score":0.5318879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03778429702201445,"score_gpt":0.3552380715350331,"score_spread":0.3174537745130186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}