{"id":"W3127562344","doi":"10.3389/fphys.2021.619442","title":"CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Ceramide; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Lipid metabolism; Inflammation; Lipid droplet; Endocrinology; Chemistry; Lipid signaling; Biology; Internal medicine; Biochemistry; Immunology; Medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002821011,0.0002870165,0.0008059027,0.0002423509,0.00006164517,0.00001930201,0.0001768282,0.000206113,0.0002385168],"category_scores_gemma":[0.000432084,0.0002789792,0.00008454393,0.0003499687,0.0004537895,0.0002164054,0.0002172317,0.0005909812,0.00003179915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739585,"about_ca_system_score_gemma":0.0004632983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00011942,"about_ca_topic_score_gemma":0.0002499158,"domain_scores_codex":[0.9973186,0.000299513,0.0005726644,0.0006441624,0.0003278815,0.0008371792],"domain_scores_gemma":[0.9990195,0.0001563577,0.0001306062,0.0003686674,0.0001126904,0.0002122029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0030082,0.00020815,0.131329,0.0002353818,0.0000413068,0.0003228356,0.0001836187,0.0001386875,0.85675,0.00002035966,0.004951513,0.002810935],"study_design_scores_gemma":[0.003863168,0.0003552989,0.6814386,0.0001325245,0.00001538813,0.00003806063,0.0002118796,0.002285883,0.3073233,0.0001075806,0.003977042,0.000251245],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953304,0.0005063987,0.0002556434,0.0001961547,0.002789438,0.0004927792,0.0001465777,0.00004034189,0.000242262],"genre_scores_gemma":[0.9909431,0.0005217332,0.006753584,0.0002994658,0.0006172428,0.00008415544,0.0001069004,0.00003971785,0.0006341043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5501096,"threshold_uncertainty_score":0.9999663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007153494055436794,"score_gpt":0.2478655875657608,"score_spread":0.240712093510324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}