{"id":"W3127587701","doi":"10.1002/mdc3.13158","title":"Laboratory‐Supported Multiple System Atrophy beyond Autonomic Function Testing and Imaging: A Systematic Review by the <scp>MoDiMSA Study Group</scp>","year":2021,"lang":"en","type":"review","venue":"Movement Disorders Clinical Practice","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Medical Research Council; Montreal Neurological Institute and Hospital; Parkinsonfonden; AOP Orphan; School of Medicine, New York University; Ono Pharmaceutical; Parkinson Canada; NIH Clinical Center; Sun Pharma; University College London Hospitals NHS Foundation Trust; Università degli Studi di Salerno; Radboud Universitair Medisch Centrum; Hirosaki University; Medizinische Universität Innsbruck; Universitat de Barcelona; National and Kapodistrian University of Athens; Merz Pharmaceuticals; Astellas Pharma; University of Tokyo; Eisai; Università degli Studi di Padova; Bundesministerium für Gesundheit; Bundesministerium für Bildung und Forschung; Eli Lilly and Company; Radboud Universiteit; Institut National de la Santé et de la Recherche Médicale; Sydney Medical School; H. Lundbeck A/S; Rosetrees Trust; Rheinische Friedrich-Wilhelms-Universität Bonn; Newcastle University; University of Sydney; University College London; University of Toronto; Imperial College London; Universität Innsbruck; PTC Therapeutics; University of Cambridge; Multiple System Atrophy Coalition; Fondation Brain Canada; Vanderbilt University Medical Center; University of Cyprus; Université de Toulouse; University of Oxford; Sapienza Università di Roma; Biogen; Aeglea BioTherapeutics; Prothena; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Michael J. Fox Foundation for Parkinson's Research; Jazz Pharmaceuticals; Universität Rostock; Deutsches Zentrum für Neurodegenerative Erkrankungen; Sunovion; Università di Bologna; European Commission; Deutsche Forschungsgemeinschaft; Christian-Albrechts-Universität zu Kiel; CHDI Foundation; McGill University; Austrian Science Fund; U.S. Department of Veterans Affairs; University of Pennsylvania; Vanderbilt University; Universidade de Lisboa; International Parkinson and Movement Disorder Society; National Institutes of Health; Dysautonomia Foundation; NHLBI Division of Intramural Research; National Institute on Aging; Robert Bosch Stiftung; Eberhard Karls Universität Tübingen; York University; Bristol-Myers Squibb; Teva Pharmaceutical Industries; National Parkinson Foundation; Pfizer; Daiichi Sankyo Company; Massachusetts General Hospital; Aarhus Universitet; Sanofi; Ontario Brain Institute; National Institute for Health and Care Research; Daiichi Sankyo Europe; Harvard T.H. Chan School of Public Health; Universidad Técnica Federico Santa María; University of California, San Diego; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Johns Hopkins University; Parkinson Society Canada","keywords":"Medicine; Neuroimaging; Atrophy; Pure autonomic failure; Spinocerebellar ataxia; REM sleep behavior disorder; Physical medicine and rehabilitation; Cerebellar ataxia; Dementia; Progressive supranuclear palsy; Neuropsychology; Autonomic function; Neuroradiology; Ataxia; Neurology; Pathology; Pediatrics; Parkinson's disease; Internal medicine; Cognition; Orthostatic vital signs; Psychiatry; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004888404,0.001078273,0.005932093,0.008372283,0.0003901564,0.001518315,0.001479295,0.001459176,0.003564717],"category_scores_gemma":[0.0188092,0.0006489513,0.006223152,0.008150291,0.0005450009,0.001458727,0.0009986249,0.0007739574,0.0002394379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001793223,"about_ca_system_score_gemma":0.006905215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008753411,"about_ca_topic_score_gemma":0.0219939,"domain_scores_codex":[0.9962726,0.00103309,0.001435178,0.0004294448,0.0006837201,0.0001459608],"domain_scores_gemma":[0.9829261,0.01062018,0.004165975,0.0002903005,0.001782301,0.0002150494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004342372,0.00001920048,0.003679043,0.9222975,0.01575633,0.0001479214,0.0001724318,0.0001045227,0.0001897448,0.0001703787,0.003739771,0.05328886],"study_design_scores_gemma":[0.0007024138,0.0002831845,0.0338226,0.7998665,0.1389726,0.001176012,0.000358394,0.0001699079,0.0001984626,0.000420423,0.0239515,0.00007802823],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001294321,0.9975425,0.00005653152,0.0002313155,0.00005023962,0.00009305293,0.0005700748,0.000003936603,0.0001579724],"genre_scores_gemma":[0.0244798,0.9730914,0.0003464798,0.0007456834,0.0001303889,0.0003898045,0.0007191651,0.000006212659,0.00009107087],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008753411,"threshold_uncertainty_score":0.02585262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04365491984965492,"score_gpt":0.360779390798229,"score_spread":0.3171244709485741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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