{"id":"W3127587701","doi":"10.1002/mdc3.13158","title":"Laboratory‐Supported Multiple System Atrophy beyond Autonomic Function Testing and Imaging: A Systematic Review by the <scp>MoDiMSA Study Group</scp>","year":2021,"lang":"en","type":"review","venue":"Movement Disorders Clinical Practice","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Medical Research Council; Montreal Neurological Institute and Hospital; Parkinsonfonden; AOP Orphan; School of Medicine, New York University; Ono Pharmaceutical; Parkinson Canada; NIH Clinical Center; Sun Pharma; University College London Hospitals NHS Foundation Trust; Università degli Studi di Salerno; Radboud Universitair Medisch Centrum; Hirosaki University; Medizinische Universität Innsbruck; Universitat de Barcelona; National and Kapodistrian University of Athens; Merz Pharmaceuticals; Astellas Pharma; University of Tokyo; Eisai; Università degli Studi di Padova; Bundesministerium für Gesundheit; Bundesministerium für Bildung und Forschung; Eli Lilly and Company; Radboud Universiteit; Institut National de la Santé et de la Recherche Médicale; Sydney Medical School; H. Lundbeck A/S; Rosetrees Trust; Rheinische Friedrich-Wilhelms-Universität Bonn; Newcastle University; University of Sydney; University College London; University of Toronto; Imperial College London; Universität Innsbruck; PTC Therapeutics; University of Cambridge; Multiple System Atrophy Coalition; Fondation Brain Canada; Vanderbilt University Medical Center; University of Cyprus; Université de Toulouse; University of Oxford; Sapienza Università di Roma; Biogen; Aeglea BioTherapeutics; Prothena; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Michael J. Fox Foundation for Parkinson's Research; Jazz Pharmaceuticals; Universität Rostock; Deutsches Zentrum für Neurodegenerative Erkrankungen; Sunovion; Università di Bologna; European Commission; Deutsche Forschungsgemeinschaft; Christian-Albrechts-Universität zu Kiel; CHDI Foundation; McGill University; Austrian Science Fund; U.S. Department of Veterans Affairs; University of Pennsylvania; Vanderbilt University; Universidade de Lisboa; International Parkinson and Movement Disorder Society; National Institutes of Health; Dysautonomia Foundation; NHLBI Division of Intramural Research; National Institute on Aging; Robert Bosch Stiftung; Eberhard Karls Universität Tübingen; York University; Bristol-Myers Squibb; Teva Pharmaceutical Industries; National Parkinson Foundation; Pfizer; Daiichi Sankyo Company; Massachusetts General Hospital; Aarhus Universitet; Sanofi; Ontario Brain Institute; National Institute for Health and Care Research; Daiichi Sankyo Europe; Harvard T.H. Chan School of Public Health; Universidad Técnica Federico Santa María; University of California, San Diego; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Johns Hopkins University; Parkinson Society Canada","keywords":"Medicine; Neuroimaging; Atrophy; Pure autonomic failure; Spinocerebellar ataxia; REM sleep behavior disorder; Physical medicine and rehabilitation; Cerebellar ataxia; Dementia; Progressive supranuclear palsy; Neuropsychology; Autonomic function; Neuroradiology; Ataxia; Neurology; Pathology; Pediatrics; Parkinson's disease; Internal medicine; Cognition; Orthostatic vital signs; Psychiatry; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004579122,0.0009548715,0.004495855,0.0001138863,0.0004028638,0.0001780833,0.0003141893,0.0002440728,0.00001525281],"category_scores_gemma":[0.01776569,0.0006294778,0.0008189219,0.0007436699,0.0001017497,0.0003279723,0.0003028056,0.001027662,0.0001074301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003909344,"about_ca_system_score_gemma":0.0005463269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001197327,"about_ca_topic_score_gemma":0.00001037584,"domain_scores_codex":[0.9903844,0.00348729,0.003173619,0.001507184,0.0008862045,0.0005613029],"domain_scores_gemma":[0.9843375,0.01017203,0.00319729,0.00149484,0.0003544129,0.0004439087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000365952,0.008529495,0.003668484,0.8434154,0.01018967,0.0005582043,0.00007335463,3.493199e-7,9.063177e-7,0.0000810748,0.01175389,0.1216926],"study_design_scores_gemma":[0.004205784,0.001389693,0.0003334705,0.2552701,0.1040072,0.00006541118,0.003060324,0.0002675262,5.79618e-8,0.00003297198,0.6309891,0.0003783176],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001177174,0.9843259,0.000220729,0.0002432984,0.0006314841,0.01359513,0.0001842976,0.0001902706,0.0004911966],"genre_scores_gemma":[0.0007927042,0.9907241,0.0004299147,0.00442108,0.0001427484,0.002711895,0.0004300849,0.0001603344,0.0001871359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6192352,"threshold_uncertainty_score":0.9996157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04365491984965492,"score_gpt":0.360779390798229,"score_spread":0.3171244709485741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}