{"id":"W3127615945","doi":"10.1128/mbio.03458-20","title":"An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Hrvatska Zaklada za Znanost; Government of Canada","keywords":"Legionella pneumophila; Vacuole; Microbiology; Effector; Endosome; Legionella; Intracellular; Pathogen; Autophagy; Lysosome; Biology; Chemistry; Cell biology; Bacteria; Biochemistry; Enzyme; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841724,0.0002821018,0.0002002633,0.000196496,0.000230056,0.0004647576,0.0001425671,0.0003897316,0.001707753],"category_scores_gemma":[0.0002917144,0.000119507,0.000152426,0.00008325331,0.0002133549,0.0003335013,0.0003690029,0.0003614398,0.000702303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035539,"about_ca_system_score_gemma":0.0001643734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493266,"about_ca_topic_score_gemma":0.0002154593,"domain_scores_codex":[0.9998784,0.00003123577,0.00001217404,0.0000183197,0.00002891416,0.00003088211],"domain_scores_gemma":[0.9997801,0.00005395486,0.0000246149,0.00004543997,0.00003366985,0.00006206377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152186,0.00002181836,0.0005998563,0.00002776963,0.000002566411,0.0002336365,0.00001665543,0.00004389109,0.9969301,0.0005123036,0.00004730968,0.001411858],"study_design_scores_gemma":[0.00002553687,0.0002278487,0.01262092,0.0000181935,0.00001089846,0.001822982,0.00008645761,0.001082192,0.9761085,0.0003744065,0.007615305,0.000006703983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898776,0.003436485,0.002921706,0.0002208491,0.00003671692,0.000009215894,0.0001313258,0.0001289796,0.0032371],"genre_scores_gemma":[0.9961292,0.0003444679,0.0008006305,0.00003222673,0.000008362777,0.000006530179,0.0001973479,0.000009732536,0.00247162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707753,"threshold_uncertainty_score":0.005713046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418245169312122,"score_gpt":0.2843224053152064,"score_spread":0.2701399536220852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}