{"id":"W3127615945","doi":"10.1128/mbio.03458-20","title":"An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Hrvatska Zaklada za Znanost; Government of Canada","keywords":"Legionella pneumophila; Vacuole; Microbiology; Effector; Endosome; Legionella; Intracellular; Pathogen; Autophagy; Lysosome; Biology; Chemistry; Cell biology; Bacteria; Biochemistry; Enzyme; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071664,0.00008204879,0.0001100579,0.00002611291,0.00006106714,0.00001886403,0.0001830282,0.0001058063,0.00001132827],"category_scores_gemma":[0.00006535214,0.00006097964,0.0000769995,0.0001068648,0.00005899362,0.000003336092,0.00007968285,0.00007245144,0.000006296552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009718812,"about_ca_system_score_gemma":0.00009415489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006824511,"about_ca_topic_score_gemma":0.0001495772,"domain_scores_codex":[0.9992456,0.00006408661,0.0001296958,0.0002391606,0.0001139581,0.0002074803],"domain_scores_gemma":[0.9994403,0.00004240645,0.00003433045,0.0003464193,0.00009133526,0.0000452636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085336,0.0001060429,0.009423166,0.00002631574,0.00001750397,0.000005867049,0.00005379216,0.00006867391,0.9882782,0.0001028295,0.0007815573,0.001027482],"study_design_scores_gemma":[0.0006821591,0.0002569887,0.0122249,0.00001493269,0.00000876489,0.00001161192,0.0002170615,0.0005452005,0.9710965,0.0001483418,0.01470059,0.00009295742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977012,0.0008080231,0.0001040686,0.0004519441,0.00008050554,0.0002382061,0.00002146173,0.000003077568,0.0005914613],"genre_scores_gemma":[0.9987384,0.0001398107,0.00009552832,0.0000979636,0.0001703127,0.00003148592,0.0001194302,0.00001192574,0.0005951372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01718175,"threshold_uncertainty_score":0.2486678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418245169312122,"score_gpt":0.2843224053152064,"score_spread":0.2701399536220852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}