{"id":"W3127646479","doi":"10.1136/bmjopen-2020-040210","title":"Piperacillin–tazobactam versus meropenem for treatment of bloodstream infections caused by third-generation cephalosporin-resistant Enterobacteriaceae: a study protocol for a non-inferiority open-label randomised controlled trial (PeterPen)","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministry of Health, State of Israel; Università di Bologna; Canadian Institutes of Health Research; Università di Pisa; Università degli Studi di Verona; European Society of Clinical Microbiology and Infectious Diseases; McGill University Health Centre; Jewish General Hospital; Tel Aviv Sourasky Medical Center; Università degli Studi di Milano; McGill University","keywords":"Meropenem; Medicine; Piperacillin/tazobactam; Tazobactam; Piperacillin; Carbapenem; Cephalosporin; Internal medicine; Antimicrobial stewardship; Intensive care medicine; Clinical trial; Randomized controlled trial; Carbapenem-resistant enterobacteriaceae; Antibiotics; Enterobacteriaceae; Antibiotic resistance; Microbiology; Pseudomonas aeruginosa; Imipenem; Biology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02450016,0.004655139,0.007638384,0.001546172,0.001735805,0.003493722,0.0025576,0.005833851,0.02889126],"category_scores_gemma":[0.01969734,0.002052564,0.004911489,0.001577756,0.003253972,0.002763548,0.001262741,0.00486744,0.00478887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002817054,"about_ca_system_score_gemma":0.008104073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008076806,"about_ca_topic_score_gemma":0.001704961,"domain_scores_codex":[0.9862486,0.008922631,0.001420067,0.001240082,0.000964186,0.001204527],"domain_scores_gemma":[0.992081,0.002376454,0.002102178,0.001173979,0.00124617,0.001020197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9680712,0.007888246,0.0003245634,0.005700168,0.001274336,0.0001117163,0.0001777803,0.001022323,0.002074888,0.001375883,0.002334512,0.009644561],"study_design_scores_gemma":[0.9800411,0.01408657,0.0004001435,0.000447315,0.0004120383,0.00001950397,0.00002300703,0.0006171436,0.0003483668,0.0005616883,0.003015571,0.00002744743],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02306665,0.001054525,0.002048211,0.0004391909,0.0007560591,0.970077,0.0008899875,0.0001069241,0.001561507],"genre_scores_gemma":[0.01849216,0.0005628986,0.003489516,0.0003669085,0.0001820076,0.9754504,0.0002718532,0.00001382542,0.001170402],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02889126,"threshold_uncertainty_score":0.1295708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09281592827625709,"score_gpt":0.4256410170367262,"score_spread":0.3328250887604691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}