{"id":"W3127714475","doi":"10.1039/d1dt00116g","title":"Surface peptide functionalization of zeolitic imidazolate framework-8 for autonomous homing and enhanced delivery of chemotherapeutic agent to lung tumor cells","year":2021,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Universiti Putra Malaysia; Ministry of Higher Education, Malaysia","keywords":"Zeolitic imidazolate framework; Surface modification; Imidazolate; Homing (biology); Peptide; Nanotechnology; Combinatorial chemistry; Chemistry; Materials science; Biochemistry; Metal-organic framework; Organic chemistry; Biology; Adsorption","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006445567,0.0002769378,0.0001017612,0.00008334251,0.00005573851,0.00009033507,0.0001740323,0.0002095642,0.0004394599],"category_scores_gemma":[0.00008441809,0.00007661897,0.0001380137,0.00006017594,0.00007189611,0.0001212945,0.0001174013,0.0001793429,0.0001831007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598086,"about_ca_system_score_gemma":0.00007880608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003701845,"about_ca_topic_score_gemma":0.0006186067,"domain_scores_codex":[0.9999548,0.000006056624,0.0000033157,0.00000995672,0.00001247542,0.00001331816],"domain_scores_gemma":[0.9999764,0.000003125422,0.000009946039,0.000001958988,0.000004373189,0.000004211176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002342298,0.000005945624,0.00002850385,0.00002027633,0.000001698716,0.00001963298,0.000005469034,0.00009403979,0.9992402,0.00003788761,0.00001095608,0.0005119747],"study_design_scores_gemma":[0.00001125796,0.0001482715,0.0006347037,0.00000225982,0.000005132995,0.00007491336,0.000007087999,0.000974423,0.9969602,0.00001241117,0.001165259,0.000004029851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994607,0.0006352497,0.003506886,0.00004242741,0.00001135772,0.00002779057,0.00009320416,0.00004533424,0.001030803],"genre_scores_gemma":[0.9953053,0.0004187235,0.003302188,0.00001819959,0.000003733303,0.00002255214,0.0001050877,0.000007948681,0.0008163042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004394599,"threshold_uncertainty_score":0.001470149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063771907395311,"score_gpt":0.2672596800570826,"score_spread":0.2566219609831295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}