{"id":"W3127723205","doi":"10.1002/stem.3344","title":"Niche-dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Toronto","funders":"Canadian Institutes of Health Research; Center on the Microenvironment and Metastasis, Cornell University; Krembil Foundation","keywords":"Forebrain; Biology; Neural stem cell; Cell biology; Myelin basic protein; Myelin; Spinal cord; Stem cell; Neuroscience; Progenitor cell; Niche; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084769,0.0001895315,0.0002566827,0.00005480216,0.0001091374,0.00004455732,0.0001774778,0.00007495011,0.00003521742],"category_scores_gemma":[0.00003442063,0.0001501845,0.000070701,0.00034185,0.00009686083,0.0001300787,0.0001535044,0.000125209,0.00001278586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001113587,"about_ca_system_score_gemma":0.00006799952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007517059,"about_ca_topic_score_gemma":0.000004193278,"domain_scores_codex":[0.997613,0.0005631227,0.0004775116,0.0005280406,0.000584703,0.0002336444],"domain_scores_gemma":[0.9987664,0.0003634235,0.0003160406,0.0003559402,0.0001182147,0.00007998721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003955,0.0001228882,0.0000786112,0.0001626033,0.000003013806,0.00002192423,0.0002778506,0.00003403319,0.9986347,0.0000850732,0.0001513199,0.0003884264],"study_design_scores_gemma":[0.0003894136,0.0001685995,0.00002082171,0.00003739496,0.00002486327,0.00002280543,0.0001251934,0.002023187,0.9969894,0.00001107212,0.00006649215,0.0001207353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982919,0.0002444458,0.000166405,0.000171339,0.0001635724,0.0006863645,0.0001839576,0.00002712799,0.00006494986],"genre_scores_gemma":[0.9985781,0.0001418059,0.00001278777,0.0002752173,0.00002237855,0.00004363771,0.000002259475,0.00002850629,0.0008953405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989154,"threshold_uncertainty_score":0.6124347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116932621968081,"score_gpt":0.2168014128681006,"score_spread":0.1956320866484198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}