{"id":"W3127767560","doi":"10.1101/2021.02.02.429403","title":"AN INULIN-TYPE FRUCTAN ENRICHED EXCLUSIVE ENTERAL NUTRITION FORMULA SUPPRESSES COLITIS THROUGH GUT MICROBIOME MODULATION AND PROMOTING EXPANSION OF ANTI-INFLAMMATORY T CELL SUBSETS","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microbial Metabolites in Food Biotechnology","field":"Nursing","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Michael Smith Health Research BC","keywords":"Colitis; Inflammatory bowel disease; FOXP3; Enteral administration; Immune system; Immunology; Ulcerative colitis; Bacteroides; Medicine; Gut flora; Bifidobacterium; Butyrate; Gastroenterology; Internal medicine; Lactobacillus; Biology; Disease; Parenteral nutrition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004406049,0.0008383154,0.001206075,0.0005544641,0.0002644578,0.0003059765,0.0007198522,0.001631337,0.00003660809],"category_scores_gemma":[0.0002474374,0.001015117,0.0001853336,0.0007773276,0.0003462504,0.0007213493,0.0007162769,0.001032508,0.000004876869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002713494,"about_ca_system_score_gemma":0.0002404478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008253465,"about_ca_topic_score_gemma":0.000006732072,"domain_scores_codex":[0.9954178,0.0005115381,0.00126496,0.001606008,0.0003938559,0.0008058643],"domain_scores_gemma":[0.9958221,0.00008862118,0.001253551,0.001615443,0.001026984,0.000193319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002087109,0.0003945124,0.001805719,0.003454061,0.00008878478,0.00005018558,0.0003910377,0.00002819171,0.9934522,0.0000788464,0.00003365415,0.00001412857],"study_design_scores_gemma":[0.001321297,0.0002444272,0.02612031,0.001346921,0.000196108,5.92843e-7,0.00005856533,0.000973928,0.9684998,0.00002446469,0.0003239999,0.0008895876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905062,0.00307527,0.0008607527,0.0001445629,0.002669787,0.001906189,0.0003942779,0.0004411263,0.000001857056],"genre_scores_gemma":[0.9689222,0.0004875706,0.02978049,0.00009351211,0.0004371185,0.00005295992,0.00002463269,0.0002008588,6.326953e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02891974,"threshold_uncertainty_score":0.9996648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100774478473325,"score_gpt":0.2342362455122664,"score_spread":0.2241587976649339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}