{"id":"W3127821223","doi":"10.1038/s41541-021-00285-9","title":"Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles","year":2021,"lang":"en","type":"article","venue":"npj Vaccines","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; European Commission; amfAR, The Foundation for AIDS Research; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Neutralization; Component (thermodynamics); Nanoparticle; Human immunodeficiency virus (HIV); Chemistry; Trimer; Virology; Nanotechnology; Materials science; Medicine; Virus; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260018,0.0001784854,0.0002370264,0.00007003873,0.0003471721,0.0000457877,0.00007316113,0.00009415747,0.0001767486],"category_scores_gemma":[0.00004988316,0.0001494509,0.00004772373,0.0001315415,0.00004435431,0.00009538804,0.0000660176,0.0001578027,0.0002090997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005313919,"about_ca_system_score_gemma":0.00005685698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008850076,"about_ca_topic_score_gemma":0.00003380368,"domain_scores_codex":[0.9987394,0.0002321478,0.000235531,0.0003383434,0.0000450778,0.0004094999],"domain_scores_gemma":[0.9995524,0.00009065903,0.00006480642,0.0001986527,0.00005282003,0.00004069881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001606443,0.0001741592,0.003504171,0.00001900391,0.0001196949,0.00003350311,0.0002419976,0.00001324901,0.9846829,0.0001295142,0.001495023,0.009426169],"study_design_scores_gemma":[0.002172283,0.0002062845,0.003441701,0.00006525424,0.00003356046,0.00006851675,0.0001862539,0.00001357356,0.9898475,0.0000357073,0.003773688,0.0001557248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928429,0.005442854,0.0001008577,0.0008276396,0.0001414609,0.0002841133,0.00005127192,0.00006978613,0.0002390833],"genre_scores_gemma":[0.9976677,0.00007989386,0.00009976966,0.00005718448,0.00001735257,0.00004632531,0.0005157727,0.00001454949,0.001501511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009270445,"threshold_uncertainty_score":0.6094432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008736594616026,"score_gpt":0.2555159623107246,"score_spread":0.2454285963645643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}