{"id":"W3127917506","doi":"10.1101/2021.02.01.429237","title":"Isoform-specific functions of Numb in breast cancer progression, metastasis and proteome remodeling","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Scheme for Promotion of Academic and Research Collaboration; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"NUMB; Alternative splicing; Cancer research; Biology; Metastasis; Gene isoform; Breast cancer; Cancer; Tumor progression; Endocytic cycle; Exon; Cell biology; Cell; Endocytosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475692,0.0001361992,0.0001457187,0.0002617837,0.0002333098,0.0003026538,0.0001056543,0.0001556513,0.002148821],"category_scores_gemma":[0.0001309194,0.0001103738,0.0001201218,0.0001996324,0.0001433313,0.0001961587,0.0002225761,0.0002216794,0.0006991632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090349,"about_ca_system_score_gemma":0.0001438884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003889357,"about_ca_topic_score_gemma":0.0006165877,"domain_scores_codex":[0.999933,0.000008126151,0.000004008254,0.00001743667,0.00002605547,0.00001125995],"domain_scores_gemma":[0.9999536,0.00000581631,0.00001241505,0.000006042736,0.000007221312,0.00001486616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001197052,0.000008769707,0.00213084,0.00004424507,0.000006374228,0.0001697351,0.00002960304,0.0001241402,0.9932327,0.0003777742,0.0001329513,0.003623157],"study_design_scores_gemma":[0.0000189339,0.00009319554,0.08094402,0.00002023453,0.00002060116,0.001842036,0.0001124826,0.004885107,0.9008186,0.0008486049,0.01038837,0.000007828427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888865,0.003633532,0.003386135,0.0001954135,0.00003338543,0.00001320316,0.0006233593,0.00008269006,0.003145795],"genre_scores_gemma":[0.9862986,0.001437466,0.003360971,0.00003525177,0.00001389931,0.00001757406,0.0009698435,0.00003380521,0.007832547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002148821,"threshold_uncertainty_score":0.007188499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118073279389257,"score_gpt":0.2250889438095381,"score_spread":0.2132816158706125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}