{"id":"W3127993692","doi":"10.1002/bies.202100043","title":"Does transcriptional heterogeneity facilitate the development of genetic drug resistance?","year":2021,"lang":"en","type":"article","venue":"BioEssays","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Epigenetics; Mechanism (biology); Drug resistance; Adaptation (eye); Gene; Drug; Microbial genetics; Drug development; Genetic variation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516459,0.0001047411,0.00009346366,0.00001310169,0.0001088025,0.00001066817,0.0001571039,0.00005999028,0.00004315446],"category_scores_gemma":[0.00002358052,0.00006325327,0.0000888036,0.00006916327,0.0001201633,0.000001241546,0.00005889296,0.00004359545,0.000007163806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001138175,"about_ca_system_score_gemma":0.0001952594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002464683,"about_ca_topic_score_gemma":0.001738182,"domain_scores_codex":[0.9991028,0.0000784523,0.0002616176,0.0002469509,0.0001571513,0.0001530669],"domain_scores_gemma":[0.9994597,0.000008434286,0.00005342979,0.0003054501,0.0001273815,0.00004558052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005360699,0.0001075106,0.005787858,0.00006708844,0.000110368,0.000002338968,0.000468891,0.0001435215,0.9891222,0.0006586493,0.00162078,0.001857244],"study_design_scores_gemma":[0.000618295,0.00002195381,0.1033059,0.00002120864,0.00002798398,0.000007048869,0.0004676162,0.00009062179,0.5166023,0.0007343801,0.3777995,0.0003032659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792658,0.002118368,0.01624957,0.0005307171,0.0002419245,0.00009792839,0.00007662571,0.000008242591,0.001410809],"genre_scores_gemma":[0.9773963,0.000157735,0.01354543,0.0001262502,0.00005254844,0.00001680395,0.0001304308,0.0000097655,0.008564718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4725198,"threshold_uncertainty_score":0.2579393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01500475107364152,"score_gpt":0.238279134394256,"score_spread":0.2232743833206145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}