{"id":"W3128028170","doi":"10.1200/jco.20.01375","title":"Addition of Lenalidomide to R-CHOP Improves Outcomes in Newly Diagnosed Diffuse Large B-Cell Lymphoma in a Randomized Phase II US Intergroup Study ECOG-ACRIN E1412","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"National Cancer Institute","keywords":"Medicine; Diffuse large B-cell lymphoma; Vincristine; Internal medicine; International Prognostic Index; Rituximab; Lenalidomide; Clinical endpoint; CHOP; Prednisone; Gastroenterology; Cyclophosphamide; Performance status; Phases of clinical research; Oncology; Lymphoma; Surgery; Randomized controlled trial; Chemotherapy; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002667195,0.001339696,0.002139537,0.0004158072,0.0003423093,0.001011761,0.0009180243,0.001088379,0.00233546],"category_scores_gemma":[0.001307583,0.0005841976,0.00125727,0.0003461927,0.0008713789,0.0006646227,0.000474339,0.002156175,0.0004335765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008325732,"about_ca_system_score_gemma":0.001199063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000608031,"about_ca_topic_score_gemma":0.001833695,"domain_scores_codex":[0.998934,0.0006917383,0.00005467789,0.0001266611,0.00007587516,0.0001170785],"domain_scores_gemma":[0.999128,0.0001881678,0.0001732454,0.00009605641,0.00005099339,0.0003634627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9353895,0.02466431,0.004036501,0.0002255687,0.001074171,0.00005071965,0.00005656901,0.0005695756,0.007059059,0.00006732102,0.0009865967,0.02582014],"study_design_scores_gemma":[0.8325483,0.157354,0.007204107,0.00001728273,0.0004378754,0.0000581383,0.00002251434,0.0005228096,0.0009496961,0.00008315506,0.0007873929,0.00001464103],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951801,0.001218723,0.0002859196,0.0002636437,0.0001393186,0.001765383,0.0003738223,0.00005066819,0.0007225152],"genre_scores_gemma":[0.9913976,0.001192549,0.00114443,0.0009251435,0.0002451664,0.002622125,0.001192286,0.00002410302,0.001256668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002667195,"threshold_uncertainty_score":0.01410562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05037879450228988,"score_gpt":0.4354927524106929,"score_spread":0.385113957908403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}