{"id":"W3128034858","doi":"10.1016/s0140-6736(21)00126-4","title":"Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":284,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"UCB Pharma","keywords":"Medicine; Placebo; Psoriasis; Population; Dosing; Clinical trial; Psoriasis Area and Severity Index; Adverse effect; Internal medicine; Clinical endpoint; Randomized controlled trial; Tolerability; Plaque psoriasis; Physical therapy; Dermatology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003358091,0.002055553,0.005144482,0.0004264544,0.0007613494,0.001975666,0.001122428,0.003253958,0.008229401],"category_scores_gemma":[0.00291519,0.001039112,0.00347568,0.0004629858,0.001556215,0.001529256,0.0007023625,0.004470706,0.001825294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008438532,"about_ca_system_score_gemma":0.001196638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171717,"about_ca_topic_score_gemma":0.001972297,"domain_scores_codex":[0.9988938,0.0005508211,0.00005652038,0.00019511,0.00009979785,0.0002040012],"domain_scores_gemma":[0.9987442,0.0003825947,0.0002921458,0.0001279406,0.00008653438,0.0003664972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9857405,0.001955772,0.0002773418,0.000669417,0.0008403687,0.00003308275,0.00004719334,0.0001081073,0.001846545,0.0001037779,0.0010863,0.007291534],"study_design_scores_gemma":[0.9826791,0.0155863,0.000752486,0.00002846386,0.0002762867,0.00002229894,0.00001168454,0.00006765515,0.00009962898,0.00011865,0.0003476233,0.00000976224],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638404,0.0177048,0.001578554,0.002138119,0.00143793,0.005970565,0.002776181,0.0003189854,0.004234524],"genre_scores_gemma":[0.97208,0.005767905,0.002803501,0.003659382,0.0009649046,0.005775958,0.001971732,0.00009362667,0.006882949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008229401,"threshold_uncertainty_score":0.02753007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03975210694711809,"score_gpt":0.2980524278399601,"score_spread":0.2583003208928419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}