{"id":"W3128082452","doi":"10.1186/s13195-021-00777-9","title":"Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Medical Research Council; Canadian Institutes of Health Research; Alzheimer Society; National Institute for Health and Care Research; Alzheimer's Society; Brain Research UK; Université Laval","keywords":"Mutation; Asymptomatic; Atrophy; Anterior cingulate cortex; Internal medicine; Asymptomatic carrier; Medicine; Pathology; Psychology; Biology; Oncology; Genetics; Neuroscience; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002038808,0.0006462848,0.0004459024,0.001089653,0.0004534843,0.0003928585,0.0002174642,0.0005508985,0.003436804],"category_scores_gemma":[0.001347365,0.0002450272,0.0001946458,0.0003771828,0.0005087439,0.0002260219,0.0002317976,0.0002284714,0.0003096218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208715,"about_ca_system_score_gemma":0.000145981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002778736,"about_ca_topic_score_gemma":0.004195333,"domain_scores_codex":[0.9998592,0.00002882696,0.0000165693,0.00003616938,0.00003344582,0.00002564977],"domain_scores_gemma":[0.9994588,0.0001348935,0.0002173589,0.00002228605,0.00005100541,0.0001157036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002318386,0.0001653701,0.8515605,0.0001042625,0.0001364126,0.05952286,0.00127235,0.0001475425,0.07355667,0.000113652,0.0005963975,0.01050546],"study_design_scores_gemma":[0.00002130088,0.0003508763,0.9702584,0.00001188485,0.00004609023,0.02737704,0.0002821503,0.0001776129,0.001208415,0.00005545103,0.0002012651,0.000009522701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996172,0.00006168425,0.00003840662,0.00001648192,0.000002864009,0.000003632791,0.00003379602,0.000003546096,0.0002223257],"genre_scores_gemma":[0.999699,0.00004319411,0.00007510203,0.00001248947,0.000008321083,0.000003888768,0.00004736568,0.000002173125,0.0001083921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003436804,"threshold_uncertainty_score":0.01149726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1144855477863432,"score_gpt":0.4266629853914084,"score_spread":0.3121774376050652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}