{"id":"W3128121522","doi":"10.1371/journal.pone.0246727","title":"Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; School of Graduate Studies, Queen's University; Queen's University","keywords":"ATP-binding cassette transporter; Mutant; ABCC1; Transmembrane domain; Biology; Wild type; Biochemistry; Cyclic nucleotide-binding domain; Alanine; Efflux; Multidrug Resistance-Associated Proteins; Nucleotide; Transporter; Amino acid; Transport protein; HEK 293 cells; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009626421,0.000510041,0.000352741,0.0001178895,0.0002491487,0.0002450686,0.0002154979,0.0003946206,0.002135019],"category_scores_gemma":[0.000195855,0.0001511379,0.0003913293,0.0001895491,0.0002184419,0.0002278329,0.0002066474,0.0004748843,0.001549541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386527,"about_ca_system_score_gemma":0.0002502557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005080304,"about_ca_topic_score_gemma":0.0005233001,"domain_scores_codex":[0.9999022,0.00001864901,0.0000158937,0.00002186232,0.00002508079,0.00001640391],"domain_scores_gemma":[0.9998162,0.00003181015,0.00006775024,0.00001899018,0.00001953981,0.00004570726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001681535,0.00003147962,0.0005323381,0.00007523691,0.00001299774,0.0006759457,0.00001910669,0.0002131268,0.9960204,0.0001762614,0.0001044907,0.001970597],"study_design_scores_gemma":[0.0001037206,0.0005413958,0.04187157,0.00002691144,0.00008025626,0.004117503,0.00009798444,0.003164339,0.9344537,0.0003506743,0.01515098,0.00004095654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903762,0.001168096,0.005871005,0.0001719677,0.00009709832,0.00004247498,0.0008830468,0.0002007627,0.001189409],"genre_scores_gemma":[0.9904518,0.000497604,0.005248603,0.00009567852,0.00002588554,0.00003453772,0.001871645,0.00005066177,0.001723555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002135019,"threshold_uncertainty_score":0.007142305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0413072913812331,"score_gpt":0.2449375648248297,"score_spread":0.2036302734435966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}