{"id":"W3128131226","doi":"10.1038/s41571-021-00473-5","title":"PD-L1 as a biomarker of response to immune-checkpoint inhibitors","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1560,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Biomarker; Concordance; Biomarker discovery; Oncology; Companion diagnostic; Immune checkpoint; Clinical trial; PD-L1; Cancer; Disease; Internal medicine; Immunotherapy; Bioinformatics; Biology; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001293575,0.001020007,0.002203325,0.001662961,0.0001314762,0.001233854,0.0008329708,0.001040451,0.001394844],"category_scores_gemma":[0.002235721,0.0002872797,0.0007389111,0.001490255,0.0004329873,0.0008537755,0.0006072524,0.002176594,0.0009298136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008320188,"about_ca_system_score_gemma":0.001156214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011316,"about_ca_topic_score_gemma":0.001897634,"domain_scores_codex":[0.9996407,0.00008278984,0.00005849744,0.00006545806,0.0001237495,0.00002880431],"domain_scores_gemma":[0.9990829,0.0005439791,0.0001392774,0.00001789121,0.0001781535,0.0000378345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000221009,0.00005270617,0.0005057952,0.01026335,0.0002390374,0.00007580683,0.00001791723,0.0004273812,0.0008256427,0.002107332,0.02172571,0.9635383],"study_design_scores_gemma":[0.0002455845,0.0005589825,0.004190713,0.01263498,0.001336802,0.001383619,0.00006403381,0.0008337311,0.001732644,0.004456829,0.972497,0.00006513736],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009533158,0.9989618,0.0001062643,0.0002887973,0.0001710064,0.000003904689,0.00002036315,0.000004106967,0.0003483571],"genre_scores_gemma":[0.001990771,0.9961817,0.0002882299,0.0006284972,0.0003830998,0.00001699303,0.00006648295,0.000001619142,0.0004426426],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002203325,"threshold_uncertainty_score":0.006841123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1525086424784524,"score_gpt":0.5349054464247085,"score_spread":0.3823968039462561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}