{"id":"W3128135108","doi":"10.1042/bst20190730","title":"Finding new edges: systems approaches to MTOR signaling","year":2021,"lang":"en","type":"article","venue":"Biochemical Society Transactions","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Rijksuniversiteit Groningen; Deutsche Forschungsgemeinschaft; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"Systems biology; PI3K/AKT/mTOR pathway; Anabolism; Signal transduction; Feed forward; Kinase; Cell signaling","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007291,0.001199839,0.001173847,0.0009718006,0.0008686553,0.002032895,0.001402762,0.001232012,0.004247494],"category_scores_gemma":[0.001740808,0.0005384968,0.001229014,0.000655846,0.002854993,0.003701671,0.002383688,0.003301332,0.0007619043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001427407,"about_ca_system_score_gemma":0.0009416214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355273,"about_ca_topic_score_gemma":0.001107293,"domain_scores_codex":[0.9995177,0.0002403008,0.00002247022,0.00009897776,0.00008767413,0.00003282107],"domain_scores_gemma":[0.9991986,0.0005167044,0.00006832825,0.00008949704,0.00006930915,0.00005746709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00005063475,0.00006811402,0.0005064375,0.0005686509,0.0001569818,0.0001580771,0.0002786372,0.07539301,0.005089358,0.8850443,0.002924996,0.02976071],"study_design_scores_gemma":[0.00002164722,0.00005628803,0.0001561327,0.00007711327,0.00003608454,0.00004771329,0.00009594367,0.118978,0.0009318751,0.8649879,0.01458036,0.00003087004],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.0155543,0.01876491,0.931316,0.005097343,0.000627965,0.0001074546,0.0002519812,0.0004350246,0.02784494],"genre_scores_gemma":[0.4910711,0.05586993,0.4356944,0.002447644,0.001496208,0.0009828204,0.0004597714,0.0002989459,0.01167912],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004247494,"threshold_uncertainty_score":0.01420927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09158535127415511,"score_gpt":0.2637594992557729,"score_spread":0.1721741479816178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}