{"id":"W3128142168","doi":"10.1007/s11064-021-03256-7","title":"Physiological and Pathological Ageing of Astrocytes in the Human Brain","year":2021,"lang":"en","type":"review","venue":"Neurochemical Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer Nederland; Universitair Medisch Centrum Utrecht; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Newfoundland and Labrador; ZonMw","keywords":"Ageing; Neuroscience; Human brain; Dementia; Pathological; Astrocyte; Cognitive decline; Alzheimer's disease; Apolipoprotein E; Aging brain; Disease; Biology; Cognition; Psychology; Central nervous system; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001212726,0.0002745647,0.0008828929,0.0002434628,0.0001993471,0.000122452,0.0008437713,0.0002607255,0.00007593382],"category_scores_gemma":[0.009520346,0.0001708972,0.0002119118,0.001028676,0.0004688964,0.00005680765,0.0005753939,0.002094093,0.00001763666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002062788,"about_ca_system_score_gemma":0.0000899401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.251825e-7,"about_ca_topic_score_gemma":5.234337e-7,"domain_scores_codex":[0.9921712,0.00478195,0.0006585338,0.000945628,0.00096406,0.0004786005],"domain_scores_gemma":[0.9938644,0.005313913,0.0001466697,0.000506634,0.00006634791,0.0001020858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003458964,0.0001231647,3.739578e-7,0.0009264439,0.000001027358,0.0006402258,0.00004784123,2.34699e-7,0.9525399,0.00932415,0.00061178,0.03578147],"study_design_scores_gemma":[0.0006396439,0.000788175,0.00006178787,0.003101719,0.00004111825,0.0007733763,0.00007092077,0.00006057537,0.4088509,0.001887058,0.5830607,0.0006640571],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2252368,0.7704559,0.00001861267,0.0008450525,0.0001217278,0.00202882,0.00003829269,0.00009404143,0.001160754],"genre_scores_gemma":[0.02093192,0.9780517,0.00003600494,0.0005328379,0.000126476,0.0001470666,0.00001979907,0.00003273618,0.0001215227],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5824489,"threshold_uncertainty_score":0.9988229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4239205060607029,"score_gpt":0.4900958808939621,"score_spread":0.06617537483325919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}